A new magnesium-containing PEG-electrolyte solution for the oral lavage of the colon

Cittadini, G; Cicco, E. De; Cata, Teuta; Dogliotti, Luca; Rosso, E.

doi:10.1016/s0009-9260(99)91006-1

“…However, in general, preparations are often given a little earlier than for colonoscopy as this allows time for reabsorption of colonic fluid content. Since magnesium ions increase the viscosity of the barium suspension, permitting better coating of the colonic mucosa,13 a magnesium-containing preparation is commonly used.…”

Section: Clinical Trialsmentioning

confidence: 99%

Laxatives for bowel clearing before investigations

2002

DTB

3

0

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“…The potentiality of magnesium ions to improve barium coating of the colonic mucosa was directly demonstrated in vivo by subjecting the patients to bowel preparation with sennosides and magnesium sulphate, or sennosides and sodium sulphate [8]. A newly designed isotonic electrolyte solution containing polyethylene glycol (PEG-ELS) and magnesium ions was employed successfully in clinical practice both as regards colon cleansing and mucosal coating [9].…”

Section: Introductionmentioning

confidence: 99%

“…The potentiality of magnesium ions to improve barium coating of the colonic mucosa was directly demonstrated in vivo by subjecting the patients to bowel preparation with sennosides and magnesium sulphate, or sennosides and sodium sulphate [8]. A newly designed isotonic electrolyte solution containing polyethylene glycol (PEG-ELS) and magnesium ions was employed successfully in clinical practice both as regards colon cleansing and mucosal coating [9].A question arises: Is the increase of barium suspension viscosity the one and only factor coming into play, or must interactions of another nature with additives of barium suspensions be invoked? Specific comprehension may be relevant for the formulation of new barium suspensions.…”

mentioning

confidence: 99%

Magnesium ions and barium coating of colonic mucosa: Is it a simple question of viscosity?

Cittadini

¹

,

Cicco

²

,

Giasotto

³

et al. 2001

Eur Radiol

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The aim of the present study was to verify whether magnesium-induced increase of barium coating of the colonic mucosa is specifically due to the increase of barium suspension viscosity. One hundred sixty-one patients scheduled for double-contrast barium enema (DCBE) were randomised in one group of 23 patients (control group, CG), and three groups of 23 pairs (G1, G2 and G3), i.e. 138 patients. The DCBE was performed with standard technique using a barium suspension with dynamic viscosity of 280 cPs (CG), or with viscosity increased to 320 cPs (G1), 2500 cPs (G2) or 3200 cPs (G3), by extemporaneous addition of MgSO4 1, 2 or 3 g in one member of the pair, Na2SO4 1, 4.2 or 8 g in the other one. Three radiologists evaluated on an ordinal scale mucosal coating and free fluid. In all magnesium subgroups barium coating was better than in CG (p < 0.008), the highest value being obtained in G2. No difference was observed as regards free fluid. Inside paired groups, mucosal coating was more effective in magnesium than in sodium members (p < 0.0002). Viscosity of barium suspension being equal inside each group, this effect must be attributed to magnesium-specific interactions with additives of the barium suspension inducing events other than viscosity changes.

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