A New Method for the Synthesis of Alkyl-Substituted 1,2,3-Triazole Compounds

Abstract

1,2,3-Trizaole derivatives have been widely used in the fields of medicine pesticide and materials. Thus, much attention has been paid to the synthesis of various 1,2,3-trizaole derivatives. However, the transformation of function group at N(1) position of 1,2,3-triazole derivatives was less studied. In this paper, in the presence of base and using copper salt as the catalyst, the sulfonyl group of 1,2,3-triazole derivatives could be transformed to other function groups in a "one-pot two-steps" manner, including benzyl, substituted benzyl, halide substituted alkyl or alkyl groups. This method exhibited mild reaction conditions and simple operation. Meanwhile, based on the captured reaction intermediate, the reaction mechanism was also proposed.

Research Advances on the Bioactivity of 1,2,3-Triazolium Salts

“…1,2,3-Triazoles are widely used in the fields of pesticides and medicines due to their broad-spectrum bioactive properties [ 1 ]. However, the increasing problem of drug resistance associated with the frequent use of triazole drugs needs to be addressed through the development of novel pharmacophores [ 2 ].…”