A New Mutation, Hb A2-Canakkale [δ10(A7)Ala→Val; HBD: c.32C&gt;T], and Other Well-Known δ Variants Identified in a Selected Cohort with Low Hb A2 Levels

Karakaya, Taner; Sılan, Fatma; Özdemir, Öztürk

doi:10.1080/03630269.2022.2083968

Cited by 1 publication

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thalassemia is a usual cause of microcytic hypochromic anemia, which occurs because of diminishing or lack of synthesis of the globin chain in hemoglobin [ 1 ]. This is dissimilar from other hemoglobinopathies, such as sickle cell disease, which are anatomic defects of hemoglobin [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Identifying Gingival Pigmentation Patterns and Skin Color and Its Co-relation With Serum Ferritin Levels in Thalassemic Patients

Gajjar¹,

Kaur²,

Girdhar³

et al. 2022

Cureus

View full text Add to dashboard Cite

Background: Patients with β-thalassemia major (β-TM), a genetic issue due to hemoglobin (Hb) synthesis disorder, require life-long erythrocyte transfusion. The purpose of this study is to evaluate and compare gingival pigmentation and skin color with serum ferritin levels of patients with β-TM, using the Dummett's oral pigmentation index (DOPI) and Fitzpatrick skin scale, respectively. Methods: A total of 100 patients were monitored at a thalassemia care center. Each patient's gingival pigmentation and skin color were matched with DOPI and the skin scale under natural light. Serum ferritin levels, the interval of blood transfusions, and iron chelation medications were studied. A gingival pigmentation score and skin color type were compared with the serum ferritin. Results: A significant correlation was found between age, serum ferritin, pigmentation score, and skin color, which means as serum ferritin level increases, gingival pigmentation score increases, and skin color darkens. Conclusion: This study evaluated the correlation between gingival pigmentation and skin color with serum ferritin levels and established gingival pigmentation as a sign of iron deposition in β-TM patients. This is the simplest and least invasive method for evaluating serum ferritin level parameters in β-TM patients.

show abstract

Section: Introductionmentioning

confidence: 99%