A New N-cis-Coumaroyltyramine Derivative from Fissistigma oldhamii

Zhu, Cheng-Cong; Luo, Yu-Xi; Wu, You; Yang, Jing-Yu; Ji, Xin-Shu; Zhou, Xue-Ming

doi:10.1007/s10600-021-03491-y

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…The latter molecule, fissistyramine, has been found only in F. oldhamii and displays a modest capacity to inhibit the proliferation of synoviocytes comparable to that of lyciumide A (IC 50 = 12.1 and 13.8 µM, respectively). A similar level of activity was evidenced with the related product N-trans-feruloyl-dopamine (39) (IC 50 = 15.6 µM) [18]. In fact, the plant stems contain a variety of natural products contributing to the inhibition of synoviocyte proliferation, including a weakly active fatty acid methyl ester (IC 50 = 38.6 µM) [76] and guaiane-type sesquiterpenoids, such as dysodensiols G-I (40-42), isolated for the first time from F. oldhamii.…”

Section: Natural Products From the Stemssupporting

confidence: 66%

“…Five coumaroyltyramine derivatives have been characterized recently from the stem of the plant, including the two analogous products lyciumide A (37) and fissistyramine (38) [18]. The former is a dopamine derivative, originally discovered in the fruits of the medicinal plant Lycium barbarum L. (goji berry) [74], and can be found in the stems of Lycium arabicum Schweinf.…”

Section: Natural Products From the Stemsmentioning

confidence: 99%

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Fissistigma oldhamii (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects

Bailly

2023

Plants

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The species Fissistigma oldhamii (Hemsl.) Merr. (Annonaceae) has long been used as a traditional herbal medicine in China to treat diverse human diseases. Decoctions from the roots of the plant (Guā Fù Mù) are used to treat body pain and inflammatory pathologies, such as rheumatic syndromes, sciatica, and osteoarthritis. The phytochemical content of the plant and the associated pharmacological activities have been analyzed. Seventy natural products were identified in the different parts of the plants, namely, the roots, stems, leaves, fruits, and seeds. The compounds comprise many tri- and tetracyclic alkaloids (aporphine-type), anthraquinones, terpenoids, flavonoids, and others. The pharmacological properties of these molecules were analyzed to point out the anti-inflammatory, antioxidant, anticancer, and/or antimicrobial effects, together with the underlying modulated pathways and molecular targets in some cases. The panel of phytoconstituents present in F. oldhamii extracts is large, with the majority of bioactive products identified in the roots and stems. Multiple molecules can contribute to the anti-inflammatory properties of the extracts. Network pharmacology analyses of the phytoconstituents are needed to better delineate the effective components and their targets.

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Section: Natural Products From the Stemssupporting

confidence: 66%

Section: Natural Products From the Stemsmentioning

confidence: 99%

Fissistigma oldhamii (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects

Bailly

2023

Plants

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“…Some of them showed inhibitory effects on the proliferation of synoviocytes. [2,3] The genus Fissistigma has been reported to contain alkaloids, sesquiterpenoids, flavonoids and chalcones. [4][5][6][7] Especially, sesquiterpenes exhibit a wide range of biological activities such as cytotoxic, anti-rheumatoid arthritis, antimicrobial and anti-inflammatory.…”

Section: Introductionmentioning

confidence: 99%

“…Previously, we have reported the bioactive constituents from the AcOEt extract of F. oldhamii including coumaroyltyramine and sesquiterpenoids. Some of them showed inhibitory effects on the proliferation of synoviocytes [2,3] . The genus Fissistigma has been reported to contain alkaloids, sesquiterpenoids, flavonoids and chalcones [4–7] .…”

Section: Introductionmentioning

confidence: 99%

Guaiane‐Type Sesquiterpenes from the Stems of Fissistigma oldhamii

Zhang

et al. 2023

Chemistry & Biodiversity

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Two new guaiane-type sesquiterpenes dysodensiols J and L, one new natural product dysodensiol K together with four known biogenetically related guaiane-type sesquiterpenes were isolated from the stems of Fissistigma oldhamii. Their structures were elucidated by detailed analysis of NMR, HR-ESI-MS, IR and Optical rotations data. Compound 1 contains an uncommon five-membered ether ring. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound 3 showed inhibitory activity with an IC 50 value of 6.8 μM. Compounds 5-7 exhibited moderate inhibitory activity with IC 50 values of 23.8, 26.6, and 27.1 μM, respectively.

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