A new non‐invasive ultrasonic method for simultaneous measurements of longitudinal and radial arterial wall movements: first <i>in vivo</i> trial

Persson, Magnus; Ahlgren, Åsa Rydén; Jansson, Tomas; Eriksson, Anders; Persson, Henry; Lindström, Kjell

doi:10.1046/j.1475-097x.2003.00504.x

Cited by 79 publications

(73 citation statements)

References 11 publications

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“…However, using modern ultrasound scanners, we observed that in large arteries of humans the inner layers of the arterial wall, the intimamedia complex, move not only in the radial direction but also in the longitudinal direction during the cardiac cycle (29). To study this phenomenon, we developed a new ultrasonic method for simultaneous high-resolution recording of both the longitudinal and the radial movements of the arterial wall noninvasively in vivo (30,10). Using this in-house developed ultrasonic method on large arteries in healthy humans, we (9) have shown that the longitudinal displacement of the intima-media complex during the cardiac cycle is of the same magnitude as the well-known diameter change.…”

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confidence: 99%

Longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines

Ahlgren

Cinthio

Steen

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

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Ahlgren ÅR, Cinthio M, Steen S, Nilsson T, Sjöberg T, Persson HW, Lindström K. Longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines. Am J Physiol Heart Circ Physiol 302: H1102-H1115, 2012. First published December 23, 2011 doi:10.1152/ajpheart.00470.2011The effects of catecholamines on longitudinal displacements and intramural shear strain of the arterial wall are unexplored. Therefore, the common carotid artery of five anaesthetized pigs was investigated using an in-house developed noninvasive ultrasonic technique. The study protocol included intravenous infusion of low-dose epinephrine (␤-adrenoceptor activation), as well as intravenous boluses of norepinephrine (␣-adrenoceptor activation). Further, the effects of ␤-blockade (metoprolol) were studied. There were significant positive correlations between pulse pressure and longitudinal displacement of the intima-media complex (r ϭ 0.72; P Ͻ 0.001), as well as between pulse pressure and intramural shear strain (r ϭ 0.48; P Ͻ 0.001). Following administration of norepinephrine, the longitudinal displacement of the intimamedia complex and intramural shear strain profoundly increased (median 190%, range 102-296%, and median 141%, range 101-182%, respectively, compared with baseline), also when given during ␤-blockade (median 228%, range 133-266%, and median 158%, range 152-235%, respectively). During infusion of low-dose epinephrine, the longitudinal displacement of the intima-media complex and intramural shear strain decreased (median 88%, range 69 -122%, and median 69%, range 47-117%, respectively, compared with baseline). In conclusion, the present study shows, for the first time, that the longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines. Increase in longitudinal displacements seems to be strongly related to ␣-adrenoceptor activation. Thus metoprolol is insufficient to counteract a profound increase in longitudinal displacement and intramural shear strain following a surge of norepinephrine. longitudinal movements; epinephrine; norepinephrine; metoprolol; vascular mechanics; ultrasound CARDIOVASCULAR DISEASE IS a leading cause of morbidity and mortality in the industrialized countries. Mental stress is considered a risk factor for cardiovascular disease both acutely, following strong emotional stress, and chronically. The mechanisms behind this association still remain unclear.In cardiovascular research, the radial movement of the arterial wall, the diameter change, has been the subject of extensive research; measurement of the diameter change of arteries is now an established tool in cardiovascular research (2,21,26), forming the basis for estimation of arterial wall stiffness. Increased stiffness of large central arteries has been shown to be an independent risk factor for cardiovascular mortality (5, 19). In contrast, there are few studies on the longitudinal movement of the arterial wa...

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confidence: 99%

Longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines

Ahlgren

Cinthio

Steen

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

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“…In a study on pigs, using piezoelectric crystals sutured onto the artery, Tozzi et al (32) recently reported a significant length reduction in the common carotid artery. To study these phenomena noninvasively in vivo, we have developed a new ultrasonic method capable of simultaneous high-resolution recording of the longitudinal and radial movements of the arterial wall (7,27).The aim of this study was to use this new unique method to noninvasively study the unexplored longitudinal movements of the intima-media complex, the adventitial region, and the surrounding tissue. For this purpose, the longitudinal movement of the common carotid artery was investigated in 10 healthy humans.…”

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confidence: 99%

Longitudinal movements and resulting shear strain of the arterial wall

Cinthio¹,

Ahlgren²,

Bergkvist³

et al. 2006

American Journal of Physiology-Heart and Circulatory Physiology

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Cinthio, Magnus, Å sa Rydén Ahlgren, Jonas Bergkvist, Tomas Jansson, Hans W. Persson, and Kjell Lindström. Longitudinal movements and resulting shear strain of the arterial wall. Am J Physiol Heart Circ Physiol 291: H394 -H402, 2006. First published February 10, 2006 doi:10.1152/ajpheart.00988.2005.-There has been little interest in the longitudinal movement of the arterial wall. It has been assumed that this movement is negligible compared with the diameter change. Using a new high-resolution noninvasive ultrasonic method, we measured longitudinal movements and diameter change of the common carotid artery of 10 healthy humans. During the cardiac cycle, a distinct bidirectional longitudinal movement of the intimamedia complex could be observed in all the subjects. An antegrade longitudinal movement, i.e., in the direction of blood flow, in early systole [0.39 mm (SD 0.26)] was followed by a retrograde longitudinal movement, i.e., in the direction opposite blood flow [Ϫ0.52 mm (SD 0.27)], later in systole and a second antegrade longitudinal movement [0.41 mm (SD 0.33)] in diastole. The corresponding diameter change was 0.65 mm (SD 0.19). The adventitial region showed the same basic pattern of longitudinal movement; however, the magnitude of the movements was smaller than that of the intimamedia complex, thereby introducing shear strain and, thus, shear stress within the wall [maximum shear strain between the intima-media complex and the adventitial region was 0.36 rad (SD 0.26). These phenomena have not previously been described. Measurements were also performed on the abdominal aorta (n ϭ 3) and brachial (n ϭ 3) and popliteal (n ϭ 3) arteries. Our new information seems to be of fundamental importance for further study and evaluation of vascular biology and hemodynamics and, thus, for study of atherosclerosis and vascular diseases. carotid artery; vascular mechanics; arterial wall movements; shearing strain in arteries; vascular ultrasound IN CARDIOVASCULAR RESEARCH, radial movement of the arterial wall, i.e., diameter change, has been the subject of extensive research. Measurement of radial movements of arteries is an established tool in cardiovascular research (8,13,17,23), forming the basis for estimation of arterial wall stiffness. Increased stiffness of large central arteries has recently been shown to be an independent risk factor for cardiovascular mortality (4). In contrast to radial movements, there has been little interest in longitudinal movements of the arterial wall, i.e., along the vessel. It has been assumed that the longitudinal movement of the arterial wall during the cardiac cycle is negligible compared with the radial movement (21). Longitudinal movement of the arterial wall has not been studied, because, until the most recent improvements in ultrasound systems, it has not been possible to detect longitudinal movement in vivo. In the 1950s, using cinematographic observations of beads sutured to the surface of exposed vessels, Lawton and Greene (15) measured the longitudinal movement of the abd...

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“…In this case, however, instead of tracking an artificial marker (Lammers et al, 2001), the spontaneous movements of existing cellular structures or components were followed. The chosen approach was to select a ROI (Persson et al, 2003) and to search for the best matching region in the next frame. The search consisted of comparing the original ROI with regions of the same size in the next frame starting from the coordinates of the original ROI and searching in different directions.…”

Section: Methodsmentioning

confidence: 99%

Toward a Concept of Stretch Coupling in Smooth Muscle: A Thesis by Lars Thuneberg on Contractile Activity in Neonatal Interstitial Cells of Cajal

Huizinga

Lammers

Mikkelsen

et al. 2010

The Anatomical Record

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The hypothesis was put forward by Thuneberg that rhythmically contracting interstitial cells of Cajal (ICC) were sensing stretch of the musculature and that this information was transmitted to smooth muscle cells via peg and socket contacts. The present study provides the evidence for the contractile nature of ICC as perceived by Thuneberg. The contractile activity is shown by video frame subtraction and by tracking areas of interest in sequential video frames. Thuneberg used neonatal ICC in culture maintained between two coverslips thereby allowing growth factors to quickly reach optimal concentrations. Contractions of ICC were seen to precede smooth muscle contractions. In addition, strong contractions were observed solely in branches of ICC. It is hoped that this communication will stimulate discussion about the contractile nature of ICC and that this phenomenon will eventually find its place amongst the physiological properties of the ICC networks of the gut musculature. Anat Rec, 293:1543Rec, 293: -1552

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A new non‐invasive ultrasonic method for simultaneous measurements of longitudinal and radial arterial wall movements: first in vivo trial

Cited by 79 publications

References 11 publications

Longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines

Longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines

Longitudinal movements and resulting shear strain of the arterial wall

Toward a Concept of Stretch Coupling in Smooth Muscle: A Thesis by Lars Thuneberg on Contractile Activity in Neonatal Interstitial Cells of Cajal

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