A new oleanane-type triterpene from Ardisia lindleyana D.Dietr and its cytotoxic activity

Abstract

A new oleanane-type triterpene from Ardisia lindleyana D.Dietr and its cytotoxic activity Abstract：A new oleanane-type triterpene, ardisiapunine A (1), together with eight known compounds were isolated from the roots of Ardisia lindleyana D.Dietr. Their chemical structures were determined by means of spectroscopic methods including HR-ESI-MS and (1D, 2D) NMR data. The absolute configuration of compound 1 was established by a single-crystal X-ray diffraction experiment. The new compound is an unusual oleanane-type triterpene bearing an acetal and a C-13-C-18 double bond. The cytotoxicity of all isolated compounds were evaluated using four human cancer cell lines, including A549, HepG2, HeLa and U87. The new compound 1 and compound 2 were weakly active but the known compound 6 exhibited a high cytotoxicity compared to cisplatin.

Structures and Tumor Cell Lines Proliferation Activities of Triterpenes Isolated from Astilbe grandis

“…While reports on triterpene lactones are currently limited, those that have been documented exhibit rich structural diversity and activity [5–8] . Din et al [9] .…”

“…[2][3][4] While reports on triterpene lactones are currently limited, those that have been documented exhibit rich structural diversity and activity. [5][6][7][8] Din et al [9] isolated triterpene-19,28lactone from Ficus foveolata, demonstrating promising potential as a PTP1B inhibitor. Similarly, Shabbir et al [10] and Tawila et al [11] isolated 3 triterpene-13,28-lactones from Spiraea brahuica and Callistemon citrinus, respectively, with ursenolide exhibiting potential antiausterity activity against the PANC-1 human pancreatic cancer cell line.…”