A New Perspective for Litholysis? Influence of Amines on the Solubility of Kindney Stones in Vitro

Abstract

It was shown that amines increase the equilibrium solubility of uric acid kidney<br>stones substantially and stabilize the process of litholysis in due course. However, these amines compete with ammonium in salt formation. Imidazole and triethanolamine are stabilize of uric acid solubility when [NH 4+ ] < 20 mM, and piperazine promotes the dissolution of uric acid if [NH 4+ ] > 46 mM. In salt solutions simulating complete cationic composition of<br>human urine, solubility of uric acid is practically the same for the systems with imidazole and piperazine and it is some lower for triethanolamine containing system