A new perspective on cutaneous leishmaniasis—Implications for global prevalence and burden of disease estimates

Expansion of urban cutaneous leishmaniasis into rural areas of southeastern Iran: Clinical, epidemiological and phylogenetic profiles explored using 7SL high resolution melting‐PCR analysis

“…It is estimated that there are 600,000 to one million new cases annually worldwide (WHO, ). Because of chronic and sustained conflicts, notably in the Middle‐East, updates on CL figures suggest that this disease represents a large‐scale global health and social challenge in the endemic countries (Bailey et al, ).…”

“Running the Gauntlet”: Formidable challenges in advancing neglected tropical diseases vaccines from development through licensure, and a “Call to Action”

“…Shown in Table 1 are the nine NTDs that are currently targeted by human vaccines (in different stages of development). [7][8][9][10][11][12][13][14][15] Also, in development, there are two • Chronic and debilitating • Ancient afflictions • Disproportionately affecting populations living in poverty • Illnesses that promote poverty vaccines for cysticercosis and echinococcosis, respectively, which would be used as veterinary vaccines to prevent transmission to humans. 16 In terms of the NTDs targeted by human vaccines, according to the Global Burden of Disease (GBD) Study 2017 together these diseases affect approximately 400 million people at any given time, 7 a population that largely represents most of the world's approximately 700 million people now believed to be living below the World Bank poverty figure of $1.90 per day.…”

Process Characterization and Biophysical Analysis for a Yeast-Expressed Phlebotomus papatasi Salivary Protein (PpSP15) as a Leishmania Vaccine Candidate

“…4 Lesions caused by CL can leave severe, disfiguring scars often causing social stigmatization. 5 Indeed, emerging evidence indicates that up to 40 million people may be affected by the chronic scarring of CL, 6 of whom a significant percentage suffer comorbid depression and other psychiatric sequelae. 7 Therefore, current global burden of disease estimates likely fail to capture the full range of human disease and its humanitarian impact.…”