A new phenolic glucoside from an Uzbek medicinal plant, Origanum tyttanthum

Abstract

A new phenolic glucoside was isolated from the aerial parts of Origanum tyttanthum, an Uzbek medicinal plant, together with 12 known compounds. The structure of the new compound was elucidated as 4-O-beta-D-glucopyranosylbenzyl-3'-hydroxyl-4'-methoxybenzoate (1) based on the spectral and chemical evidence.

The Potential Pharmacological and Medicinal Properties of Neem (Azadirachta indica A. Juss) in the Drug Development of Phytomedicine

“…Neems extracts show antiparasitic effect on most body parasites [55]. Neem leaves aqueous extract is a recommended standard treatment for external parasitic infestation without any less side as reported in India [7].…”

“…Apart from the use of neem against malaria, its traditional role in the treatment of urinary disorders, skin disease, diabetes, fungi infections and viral diseases has been demonstrated [14]. Neem twigs contain antiseptic properties that make its use in dental hygiene very effective, in the local community in India and parts of Africa [55]. In the Sahel countries, neem has been used for wind shields and prevents the spread of the Sahara Desert when applied in alley cropping [32].…”

“…In most regions of south East Asia and the communities in India the use of neem twigs and leaves to brush the teeth is a common practice and keep the gums free of periodontal disease and other oral infection. The ancient Ayurvedic practice of using neem to heal and rejuvenate gum tissue and to prevent cavities and gum disease has been demonstrated in modern clinical studies [36,55].…”

“…Neem is bitter in nature with stomachic and antipruritic properties [25], and very useful in revitalizing patients suffering from metabolic diseases like diabetes [55]. The administration of a table spoon (5 ml) leaves of juice of neem without food, early in the morning for 3 months can control diabetes in patients [55]. Neem leaves chewed or taken daily in powdered form is also effective in diabetes management [25].…”

“…Neem leaf aqueous extract can effectively reduce oral squamous cell carcinoma induced by 7, 12-dimethylbenz[a] anthracene (DMBA) [41], as shown by the reduced incidence of neoplasm [4]. Neem can express its chemopreventive effect in the oral mucosa through the regulation of glutathione and its metabolic enzymes [55]. Neem with its depurative effects can purify the blood and reduces the body heat.…”