A new polymethylmetacrylate membrane improves the membrane adhesion of blood components and clinical efficacy

Masakane, Ikuto; Esashi, Shiho; Yoshida, Asami; Chida, Tetsuro; Fujieda, Hiroaki; Ueno, Yoshiyuki; Sugaya, Hiroyuki

doi:10.1186/s41100-017-0112-0

Cited by 17 publications

(18 citation statements)

References 22 publications

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“…The newly developed PMMA membrane, NF, was reported to suppress platelet activation during dialysis by reforming the membrane surface and have the same adsorption property as the conventional PMMA membrane, BG [12,13]. Activated platelets are related directly or indirectly to the development of the inflammatory response: activated platelets release pro-inflammatory substances [23] and induce the production of pro-inflammatory substances from white blood cells by activation that is induced by forming a complex [24].…”

Section: Discussionmentioning

confidence: 99%

“…Based on the findings described above, we suspect that PS membranes that have inferior biocompatibility may have been included in the PS group in this study. It has been reported that NF has a lower platelet activation property compared with conventional PMMA membranes [12,13] Results were expressed as the mean ± standard deviation inflammatory cytokines, and the released cytokines directly and indirectly activate other platelets and lead to a reduction in the platelet count. NF can remove inflammatory cytokines by adsorption.…”

Section: Discussionmentioning

confidence: 99%

“…Filtryzer® NF (NF) is the new PMMA dialyzer with an improved hemocompatibility that results from reforming its surface and it also has a protein adsorption property, which is similar to previous PMMA dialyzers [12,13]. Oshihara et al reported that for NF, fibrinogen adsorption and platelet adhesion on the membrane were less than that of the conventional PMMA membrane, Filtry-zer® BG (BG) [12].…”

Section: Introductionmentioning

confidence: 98%

“…Oshihara et al reported that for NF, fibrinogen adsorption and platelet adhesion on the membrane were less than that of the conventional PMMA membrane, Filtry-zer® BG (BG) [12]. Additionally, Masakane et al reported that changes in the platelet count and peripheral circulation blood pressure during dialysis were less than that observed with the BG membrane [13].…”

Section: Introductionmentioning

confidence: 99%

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The clinical evaluation of novel polymethyl methacrylate membrane with a modified membrane surface: a multicenter pilot study

et al. 2018

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Background: Polymethyl methacrylate (PMMA) membranes have the unique property of adsorption, which can remove medium-and large-weight molecular substances that cannot be removed by normal hemodialysis and hemodiafiltration. Filtryzer® NF (NF) is a newly developed PMMA membrane that suppresses platelet adhesion on the membrane surface and retains an adsorption property. NF is expected to improve inflammatory conditions and clinical symptoms in hemodialysis patients compared with conventional PMMA membranes.Methods: Thirty-seven maintenance hemodialysis patients treated with polysulfone (PS) membranes and who had detectable chronic inflammation were enrolled into the study. The patients were randomly allocated into the NF and PS groups and observed for 1 year. C-reactive protein (CRP) values were measured as the primary endpoint. Nutrition, blood cell count, and dialysis itchiness were evaluated as secondary endpoints.Results: Significant differences in CRP values were not found between the NF and PS groups. In the PS group, the creatinine generation rate (%CGR) and platelet count, which were included in nutrition and blood cell count, respectively, significantly decreased after 6 and 9 months compared with the start of study, but these parameters did not significantly change in the NF group within 1 year. Dialysis itchiness in the NF group was significantly improved compared with the PS group after 9 months.Conclusions: Our results showed that a new PMMA membrane, NF, has a potential to maintain nutritional conditions and the platelet counts and improve dialysis itchiness.Trial registration: This study is retrospectively registered with the Clinical Trials Registry of the University Hospital Medical Information Network on February 17, 2015 (registration ID, UMIN000016567).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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The clinical evaluation of novel polymethyl methacrylate membrane with a modified membrane surface: a multicenter pilot study

et al. 2018

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“…Ultrafiltration rate during each dialysis session was no more than 8.9 mL/h/kg. The total amounts of albumin in the effluent dialysate by using NF-1.6H® (4-h duration, blood flow 270 mL/min, dialysate flow 500 mL/min) was reported to be about 1.8 g/HD session [9]. She discontinued HD after 11 sessions, at which time her serum creatinine level was decreased to around the baseline value 28 days after discontinuation of HD.…”

Section: Casementioning

confidence: 99%

Rhabdomyolysis-induced acute kidney injury requiring hemodialysis after a prolonged immobilization at home in 2 morbidly obese women: case reports with literature review

et al. 2020

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Background: Rhabdomyolysis may develop into acute kidney injury (AKI), a life-threatening complication. Obese people are at risk for rhabdomyolysis due to prolonged immobilization. However, there are only a few reports of rhabdomyolysis-induced AKI due to prolonged immobilization after falls in morbidly obese people. Myoglobin is a causative compound for rhabdomyolysis-induced AKI, but the lack of treatments targeting its mechanism is a problem. Case presentation: Two morbidly obese women (body mass index > 40.0 kg/m 2) who fell on the floor at home and remained in the same posture for more than 12 h developed rhabdomyolysis-induced AKI. Both patients received aggressive fluid resuscitation but required hemodialysis because of persistent oliguria. They underwent 11 and 2 intermittent hemodialysis (HD) sessions with a conventional polymethylmethacrylate (PMMA) high-flux dialyzer, respectively, and their renal functions returned to baseline after withdrawal of HD. Conclusions: We should be aware that morbidly obese people are at risk for rhabdomyolysis-induced AKI due to prolonged immobilization, such as after falls. At present, prophylactic renal replacement therapy (RRT) is not recommended for rhabdomyolysis. We need to reevaluate whether RRT using the appropriate membranes to effectively remove myoglobin including the PMMA membrane can improve the renal outcome in patients with rhabdomyolysis-induced AKI.

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Antithrombogenic poly(2-methoxyethyl acrylate) elastomer via triblock copolymerization with poly(methyl methacrylate)

Kurokawa

Endo

Bito

et al. 2021

Polymer

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A new polymethylmetacrylate membrane improves the membrane adhesion of blood components and clinical efficacy

Abstract: Background: Hemodialysis with polymethylmetacrylate (PMMA) membrane dialyzers allows unique protein adsorption. New PMMA dialyzers should demonstrate equivalent protein adsorption, but improved hemocompatibility.

Cited by 17 publications

References 22 publications

The clinical evaluation of novel polymethyl methacrylate membrane with a modified membrane surface: a multicenter pilot study

The clinical evaluation of novel polymethyl methacrylate membrane with a modified membrane surface: a multicenter pilot study

Rhabdomyolysis-induced acute kidney injury requiring hemodialysis after a prolonged immobilization at home in 2 morbidly obese women: case reports with literature review

Antithrombogenic poly(2-methoxyethyl acrylate) elastomer via triblock copolymerization with poly(methyl methacrylate)

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