A new potentiometric sensor for the determination of ketamine hydrochloride in ampoules and urine

Shawish, Hazem M. Abu; Saadeh, Salman M.; Tamos, Hassan; Abed-Almonem, Khalid I.; khalili, Osama Al

doi:10.1039/c4ay01986e

Cited by 22 publications

(2 citation statements)

References 53 publications

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“…The potential response remained constant over the pH range 2.4–8.5 for the two sensors as shown in Figure S3. At lower pH values, the potential readings decreased due to protonation of the ionophore compound, which loses its capacity to complex Benz + in the paste phase [70–73]. On the other hand, the decrease in potential above pH 8.5 may be due to precipitation of Benz and formation of deprotonated Benz species (pKa=9.26 [74]).…”

Section: Resultsmentioning

confidence: 99%

Novel Zn‐Fe LDH/MWCNTs and Graphene/MWCNTs Nanocomposites Based Potentiometric Sensors for Benzydamine Determination in Biological Fluids and Real Water Samples

2021

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Two sensitive and selective potentiometric sensors based on zinc‐iron layered double hydroxides/multiwalled carbon nanotubes (Zn−Fe LDH/MWCNTs) (sensor I) and graphene/multiwalled carbon nanotubes (Gr/MWCNTs) (sensor II) nanocomposites were developed for benzydamine hydrochloride (Benz) determination. The investigated sensors displayed excellent Nernstian slopes 58.5±0.7 and 59.5±0.5 mV decade−1, detection limits 8.3×10−7 and 1.9×10−7 mol L−1, long lifetimes, adequate selectivity, high chemical, and thermal stability within pH range of 2.4–8.5 for sensors І and ІІ, respectively. The surface morphology of sensors was analyzed using a Transmission Electron Microscope (TEM). The analytical method was efficiently implemented for Benz determination in biological fluids and surface water samples.

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Section: Resultsmentioning

confidence: 99%

Novel Zn‐Fe LDH/MWCNTs and Graphene/MWCNTs Nanocomposites Based Potentiometric Sensors for Benzydamine Determination in Biological Fluids and Real Water Samples

2021

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“…Considering these merits, ISEs are getting more attention as routine tools of chemical analysis in industry, clinical and environmental analyses. [22][23][24][25][26] Coated-wire ion-selective electrodes that were employed to overcome the problems associated with conventional ISE's 27,28 still suffer some shortcomings such as giving unreliable measurements due to the fluctuation of the electric potential. 29 New measures must be introduced to the working electrodes to alleviate or eliminate these effects and carbon-paste electrodes (CPE's) 30 appear to be suitable alternatives.…”

Section: Introductionmentioning

confidence: 99%

Determination of Atomoxetine Hydrochloride in Biological Fluids Using Potentiometric Carbon Paste Electrode Modified by TiO2 Nanoparticles

Shawish

Saadeh

Tamous

et al. 2018

ACSi

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Endeavors to improve the limit of detection for atomoxetine-selective electrode were documented. Simple potentiometric carbon paste electrodes (CPEs) based on atomoxetine-derivatized with tetraphenylborate (ATM-TPB) or phosphotungstic acid (ATM-PTA) as ion-pairs decorated with TiO 2 nanoparticles and sodium tetraphenylborate (Na-TPB) as additives were most useful. Parameters affecting the performance of the electrodes were investigated, such as paste composition, type of plasticizers, kind of electroactive materials and interfering species. The electrodes were notable for bringing down the detection limit to 8.0 × 10-7 M and 9.2 × 10-7 M, wide linear ranges 1.1 × 10-6-1.0 × 10-2 M and 1.75 × 10-6-1.00 × 10-2 M, slope 58.7 ± 0.5 mV/decade and 67.2 ± 0.8 mV/decade, respectively. Importantly, the potential reading became more stable and rapidly attained in the presence of additives. The selectivity for the drug over other species such as inorganic and organic cations, as well as different excipients that are likely incorporated in pharmaceutical preparations was high making their effect negligible on the response of the electrodes. The sensors, as indicator electrodes, were successfully applied for determination of the drug in pharmaceutical preparation, urine and serum with good accuracy, excellent recovery and efficiency.

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A carbon nanotubes/graphite paste electrode impregnated with stavudine-imprinted polymer as a stavudine selective sensor

Alizadeh

Karimian

Ganjali

2019

Ionics

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A new potentiometric sensor for the determination of ketamine hydrochloride in ampoules and urine

Abstract: Ketamine drug in urine and pharmaceutical preparations was determined by a new chemically modified carbon paste electrode (CMCPE) based on an ion-exchanger of ketamine hydrochloride with sodium tetraphenylborate (KT-TPB) as a chemical modifier.

Cited by 22 publications

References 53 publications

Novel Zn‐Fe LDH/MWCNTs and Graphene/MWCNTs Nanocomposites Based Potentiometric Sensors for Benzydamine Determination in Biological Fluids and Real Water Samples

Novel Zn‐Fe LDH/MWCNTs and Graphene/MWCNTs Nanocomposites Based Potentiometric Sensors for Benzydamine Determination in Biological Fluids and Real Water Samples

Determination of Atomoxetine Hydrochloride in Biological Fluids Using Potentiometric Carbon Paste Electrode Modified by TiO2 Nanoparticles

A carbon nanotubes/graphite paste electrode impregnated with stavudine-imprinted polymer as a stavudine selective sensor

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