A new process for Na2Ca(HPO4)2 synthesis and its application as a heterogeneous catalyst in Knoevenagel condensation

Abstract

<jats:p>The novelty of this work is to propose a new process consisting to the modification of triple superphosphate (TSP) by sodium nitrate (NaNO3) for the preparation of a heterogeneous catalytic support Na2Ca(HPO4)2 (calcium hydrogen disodium phosphate). This product has been characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and infrared spectroscopy (IR). The catalytic activity of Na2Ca(HPO4)2 was examined in Knoevenagel condensation between 4-chlorobenzaldehyde and malononit rile as a model reaction. The optimization of the reaction operating conditions was carried out based on a study of the effect of various parameters, namely reaction time, the catalyst charge, the nature, and volume of solvent on the reaction yield. From these considerations, this catalyst proves its efficiency since it allows to obtain the product with excellent yields in a short reaction time. Moreover, it has been reused several times without any significant loss of its activity. The process developed herein can be considered as an ecological and economical method because the catalyst used is non-toxic, cost-effective and easy to prepare.</jats:p>

Improvement of the catalytic performance of hybrid nanocomposite based on phosphate-benzimidazole in Knoevenagel condensation

“… Entry Catalyst Conditions Yield a % (Refs.) 1 Fe 3 O 4 MNPs-OSO 3 H 10 mg, 3 ml H 2 O, reflux, 10–145 min 80-97 [ 41 ] 2 Clay A, PC-A 100 mg, 3 ml EtOH/H 2 O, 40 °C, 5–120 min 21-98 [ 42 ] 3 [MML-PDO][OAc] 10 mol%, 1 ml H 2 O, r.t, 7–600 min 95-99 [ 43 ] 4 Na 2 Ca(HPO 4 ) 2 6 mg, 3 ml EtOH, r.t, 10–65 min 82-97 [ 44 ] 5 DCPD 10 mg, 3 ml EtOH, r.t, 10 min 84-96 [ 32 ] 6 R 2 (1MCl 2 -2NaPO 3 ) 6 mg, 3 ml EtOH, r.t, 3–30 min 85-98 (Present work) a Isolated yield. …”

“…In this context, we will present a suggestion of Knoevenagel condensation mechanism by using a new heterogeneous catalyst R 2 (1MCl 2 -2NaPO 3 ) in Scheme 3 . The mechanism has already been planned [ 44 ]. First, a basic site removes a proton from the active methylene grouping of acidic nature, forming a carbanion.…”

Comparative study between the Titanium Phosphate TiP2O7 and the Phosphate Fertilizers in the catalysis of the Quinazolin-4(3H)-one derivatives synthesis

“…As a continuation of the previous works developed by our researchers [27][28][29][30][31][32][33][34][35][36][37][38][39] , which consist on the valorization of Moroccan phosphates in the field of organic synthesis, and the development of green and sustainable chemistry, this paper reports the first and an easy preparation method for TiP2O7 from the modifications of phosphate fertilizers MAP, DAP and TSP by titanium tetrachloride (TiCl4). The characterization of TiP2O7 was realized using spectroscopic and microscopic technics such as XRD, IR, SEM, and EDX.…”

Valorization of the Modified Mono Ammonium Phosphate by Cobalt in the Synthesise of 3,4‐Dihydropyrano[c]chromene Derivatives

“…As a continuation of the previous studies published by our researcher's team on the design and application of phosphate catalysts in organic reactions . In order to valorize the Moroccan phosphate, one proposes a process for the preparation of Co 3 (PO 4 ) 2 , by a simple and less expensive method compared to that reported previously, that consists to modify the fertilizer phosphates mono‐ammonium phosphate MAP by Co(NO 3 ) 2 .…”