A new protocol for the construction of pyrrolo[4,3,2-de]quinolinones

Slezkin, Maksim S.; Mantrov, S. N.

doi:10.1016/j.mencom.2009.05.016

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Mitochondria are considered one of the most crucial organelles in cells due to their involvement in energy generation and cellular behaviors including cellular redox potential regulation, signal transduction, gene expression, and intracellular ion transport across the membrane. − Moreover, mitochondria also play a decisive role in the regulation of cell survival and apoptosis. , Cancer cells exhibit high metabolic activity and extensive metabolic adaptations, making them more vulnerable to mitochondrial dysfunction compared to normal cells . Therefore, inducing mitochondrial dysfunction or implementing therapy specifically targeting mitochondria has emerged as a promising approach for precise cancer treatment and has garnered increasing attention. ,− …”

Section: Introductionmentioning

confidence: 99%

A Mitochondria-Targeted NIR-II Molecule Fluorophore for Precise Cancer Phototheranostics

Zhao,

Chen,

Liu

et al. 2023

J. Med. Chem.

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Subcellular organelle mitochondria are becoming a key player and a driver of cancer. Mitochondrial targeting phototheranostics has attracted increasing attention for precise cancer therapy. However, those phototheranostic systems still face great challenges, including complex and multiple components, light scattering, and insufficient therapeutic efficacy. Herein, a molecular fluorophore IR-TPP-1100 was tactfully designed by molecular engineering for mitochondria-targeted fluorescence imaging-guided phototherapy in the second near-infrared window (NIR-II). IR-TPP-1100 not only exhibited prominent photophysical properties and high photothermal conversion efficiency but also achieved excellent mitochondria-targeting ability. The mitochondria-targeting IR-TPP-1100 enabled NIR-II fluorescence and photoacoustic dual-modality imaging of mitochondria at the organism level. Moreover, it integrated photothermal and photodynamic therapy, obtaining remarkable tumor therapeutic efficacy by inducing mitochondrial apoptosis. These results indicate that IR-TPP-1100 has great potential for precise cancer therapy and provides a promising strategy for developing mitochondria-targeting NIR-II phototheranostic agents.

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