A New Rare Halogenated Depside from Lichen and Study of its Anti‐Proliferative Activity

Abstract

Lichens are (Permotrema parlatum) a symbiotic association of algae and fungus belonging to the family Parmeliaceae. Some of lichen species are consumable and used as an active ingredient for preparation exotic spices as well as folklore medicine to cure different kind of ailments. A specimen of lichen was collected from Munner in Kerala State of South India for its chemical profiling. Chemical analyses of diethyl extract of the defatted lichen led to the isolation of six phenols 1‐6 with variation of relative abundance. Amongst them, the relative abundance of compound 3 was maximum (1% of crude extract) and it was identified as atranorin. The structures of known compounds were identified in comparison with their 1H & 13C NMR and mass data with published values available in literature. In vitro, bioassay of anti‐proliferative activity of these compounds has been conducted against various human cancer cell lines in comparison with paclitaxel as control using SRB assay.