A New Remotely Controlled Unit for the Treatment of Uterine Carcinoma

O’Connell, D; Howard, N.; Joslin, C. A.; Ramsey, N. W.; Liversage, W. E.

doi:10.1016/s0140-6736(65)90871-8

Cited by 79 publications

(13 citation statements)

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“…Traditionally, low‐dose rate (LDR) intracavitary brachytherapy has been the standard treatment for uterine cervical cancer. However, since its initial introduction in the 1960s by Henschke 4 and O’Connell, 5 HDR remote after‐loading brachytherapy has become widely used in Asia, Europe and North America.…”

Section: Discussionmentioning

confidence: 99%

Radical radiotherapy with high‐dose‐rate brachytherapy for uterine cervix cancer long‐term results†

Khor

Tuan

Hee

et al. 2007

Australasian Radiology

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The aim of this is to report the results of radical radiotherapy in carcinoma of the cervix treated by high-dose rate (HDR) intracavitary brachytherapy and external beam radiotherapy (XRT) at a single centre in Singapore. This is a retrospective analysis of 106 consecutive cases with histologically proven cervical cancer, treated by HDR brachytherapy and XRT at the Mount Elizabeth Hospital from 1990 to 1993. External beam radiotherapy to the pelvis was delivered with 6 MV photons, to 45-50.4 Gy in 1.8 Gy fractions. High-dose-rate brachytherapy comprised two to three applications of an intrauterine tandem with paired ovoids, to a median dose of 18 Gy to point 'A', carried out during XRT. All 106 patients completed treatment. Their ages ranged from 32 to 80 years (median 57 years). Most patients presented with stage II or III disease (44 and 37%, respectively) and with squamous cell carcinoma (91%). Median follow-up time was 59 months (range 2-169 months). The 5-year relapse-free survival rate across all stages was 71%. The corresponding overall survival rate was 69%. Local control was achieved in 86 patients (81%); six patients had residual disease (6%), and 14 patients had local recurrence (13%). Fourteen patients developed metastatic disease (13%). On univariate analysis, tumour stage, haemoglobin level, number of brachytherapy treatments and overall treatment time were found to be prognostic factors for overall survival. Late complications were mild (Radiation Therapy Oncology Group score 1-2), except for one patient with grade 4 rectal toxicity. The complication rates were 8, 14 and 45%, respectively, for the rectum, bladder and vagina (stenosis). The use of two to three fractions of HDR intracavitary brachytherapy in addition to pelvic XRT achieves good outcomes.

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Section: Discussionmentioning

confidence: 99%

Radical radiotherapy with high‐dose‐rate brachytherapy for uterine cervix cancer long‐term results†

Khor

Tuan

Hee

et al. 2007

Australasian Radiology

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“…Traditionally, LDR intracavitary brachytherapy was accepted as the standard treatment. Since early 1960, Henschke et al (24) and O'Connell et al (25) introduced HDR remote afterloading brachytherapy. This technique has been widely used in Asia and Europe.…”

Section: Discussionmentioning

confidence: 99%

Phase III randomized trial comparing LDR and HDR brachytherapy in treatment of cervical carcinoma

Lertsanguansinchai

Lertbutsayanukul

Shotelersuk

et al. 2004

International Journal of Radiation Oncology*Biology*Physics

106

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“…Since 1965 the industrially manufactured Cathetron [14] (TEM Instruments) has been distributed. It worked with 9 linear 60 Co sources and was used for the treatment of gynaecological tumours as well as for carcinomas of the bronchus and oesophagus and mould irradiations.…”

Section: Introductionmentioning

confidence: 99%

Comparison of 60Cobalt and 192Iridium Sources in High Dose Rate Afterloading Brachytherapy

Richter¹,

Baier²,

Flentje

2008

Strahlenther Onkol

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A New Remotely Controlled Unit for the Treatment of Uterine Carcinoma

Cited by 79 publications

References 1 publication

Radical radiotherapy with high‐dose‐rate brachytherapy for uterine cervix cancer long‐term results†

Radical radiotherapy with high‐dose‐rate brachytherapy for uterine cervix cancer long‐term results†

Phase III randomized trial comparing LDR and HDR brachytherapy in treatment of cervical carcinoma

Comparison of 60Cobalt and 192Iridium Sources in High Dose Rate Afterloading Brachytherapy

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