A New Serratane Triterpenoid from Lycopodiella cernua

Abstract

农业农村部华南热带农业环境重点实验室 广东省生态循环农业 重点实验室 广东省现代生态循环农业工程中心 广州 510642) 摘要 利用多种色谱分离方法对垂穗石松的化学成分进行研究, 从其全株的乙醇提取物中分离得到 2 个化合物, 用 MS 和 NMR 等多种现代波谱技术确定了化合物的结构, 经鉴定分别为 3β,14α,15α,21β-四羟基-15-(3'-甲氧基-4'-羟基苯甲 酰)-千层塔烷(1)和 16-酮基-3β,21α-二羟基-14-千层塔烯(2). 其中化合物 1 为新化合物, 2 个化合物均为首次从小石松属 植物分离.

Discovery of Cyclic Diarylheptanoids as Inhibitors against Influenza A Virus from the Roots of Casuarina equisetifolia

“…The antiviral activity against influenza A virus A/WSN/33 and cytotoxicity in MDCK cells of compounds 1 – 9 was determined according to our previously reported methods of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. , The positive control was ribavirin. The inhibitory effect against H1N1 virus and cell viability of ribavirin is shown in Figure S44.…”

Bioactive Usual and Unusual Triterpenoids Derived from Natural Sources Used in Traditional Medicine

“…Serratanes were isolated from the whole plant of L. cernua , including 3 β ,14 α ,15 α ,21 β ‐tetrahydroxyserrat‐15‐(3′‐methoxyl‐4′‐hydroxybenzoate) ( 152 ) and 16‐oxoserrat‐14‐en‐3 β ,21 α ‐diol ( 153 ). The compounds 152 and 153 were evaluated for their anti‐influenza A virus (IAV) properties against A/WSN/33 (H1N1) and showed 9 % and 36 % inhibition activity at 50 μM, respectively [157] …”

“…The compounds 152 and 153 were evaluated for their antiinfluenza A virus (IAV) properties against A/WSN/33 (H1N1) and showed 9 % and 36 % inhibition activity at 50 μM, respectively. [157] Lycopodium complanatum L. (Lycopodiaceae) is commonly known as club moss and is traditionally used in herbal medicine to treat rheumatism, contusions, hepatitis, and scalds. Eight serratanes were isolated from L. complanatum ethyl acetate extract, namely lycomplanatums A -H. The compounds lycomplanatum B (154) and lycernuic A (155) showed moderate antiproliferative effects, particularly for MCF-7 (IC 50 = 13.8-44.7 μM).…”