A New Sesquiterpene Ester from <i>Celastrus orbiculatus</i> Reversing Multidrug Resistance in Cancer Cells

Kim, Se Eun; Kim, Young Ho; Lee, Jun Young; Kim, Young Choong

doi:10.1021/np9702392

Cited by 58 publications

(47 citation statements)

References 9 publications

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“…Subfraction F [3][4] was further purified by preparative HPLC (YMC-pack ODS-AM, 250 × 20 mm i.d., 85% MeOH in H 2 O) to afford compound 1 (t R = 29 min, 14.7 mg). Fraction F 5 (eluted by petroleum ether/acetone, 100:10 and 100:15), using the above MPLC (67−87% MeOH in H 2 O), provided 12 subfractions F 5-1 −F [5][6][7][8][9][10][11][12] , and the following purification of F 5-1 by the Computational Methods. Details have been previously reported.…”

Section: ■ Introductionmentioning

confidence: 99%

Isolation and Characterization of Sesquiterpenes from Celastrus orbiculatus and Their Antifungal Activities against Phytopathogenic Fungi

Wang¹,

Zhang

Ren

et al. 2014

J. Agric. Food Chem.

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Celastrus orbiculatus is an insecticidal plant belonging to the Celastraceae family. In this survey on the secondary metabolites of plants for obtaining bioactive substances to serve agriculture, the chemical constituents of the fruits of C. orbiculatus were investigated. This phytochemical investigation resulted in the isolation of nine new and one known sesquiterpene. Their structures, especially the complicated stereochemical features, were elucidated on the basis of extensive NMR spectroscopic data analyses, time-dependent density functional theory CD calculations, and the CD exciton chirality method. Biological screenings disclosed that these sesquiterpenes showed antifungal activities against six phytopathogenic fungi. The results of our phytochemical investigation further disclosed the chemical components of C. orbiculatus, and biological screening implied that it may be potentially useful to protect crops against phytopathogenic fungi and the bioactive compounds may be regarded as candidate agents of antifungal agrochemicals for crop protection products.

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Section: ■ Introductionmentioning

confidence: 99%

Isolation and Characterization of Sesquiterpenes from Celastrus orbiculatus and Their Antifungal Activities against Phytopathogenic Fungi

Wang¹,

Zhang

Ren

et al. 2014

J. Agric. Food Chem.

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“…-Celastrus paniculatus (Celastraceae) is an evergreen shrub distributed throughout Hengchun peninsula of Taiwan, India, and Malaysia [1]. The family Celastraceae is well known for producing dihydroagarofuran derivatives and alkaloids [2], some of which exhibit insecticidal [3], antitumor [4] [5], anti-inflammatory [6], multidrug-resistance (MDR) reversing [7] [8], and immunosuppressive [9] activities. Moreover, seed oil of C. paniculatus has been reported to improve memory [10] and intestinal complaints [11] [12], and display antioxidant [13], and hypolipidemic [14] effects.…”

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confidence: 99%

New Dihydroagarofuranoid Sesquiterpenes from Celastrus paniculatus

Weng

Yen

2010

Helvetica Chimica Acta

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The six new dihydro-b-agarofuranoid sesquiterpenes 1 -6 and three known compounds were isolated from the whole plant of Celastrus paniculatus. The structures including relative configurations were elucidated by means of spectroscopic analyses. Compounds 1 -6 were evaluated for cytotoxicity against a panel of three human-tumor cell lines.Introduction. 14] effects. In our preliminary cytotoxicity screening for the genus Celastrus in Taiwan, the whole plant extract of C. paniculatus showed in vitro activity. In this article, we report the isolation and structural elucidation of the six new sesquiterpenes 1 -6 1 ) and of three known compounds, including a dihydro-b-agarofuranoid sesquiterpene,

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“…The new compound 1 was isolated as amorphous, optically active powder ([a] MS and 13 C-NMR analyses. UV Absorptions at 231, 274, and 281 nm were similar to those of orbiculin A [7], and suggested the presence of aromatic moieties. The presence of ester C¼O groups was indicated by IR bands at 1746 and 1718 cm Table 1).…”

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confidence: 71%

A New Dihydroagarofuranoid Sesquiterpene and Antituberculosis Constituents from the Root of Microtropis japonica

Chou

Chen

et al. 2008

Chemistry & Biodiversity

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A new dihydroagarofuran-based sesquiterpene, 15-acetoxyorbiculin A, was isolated from the root of Microtropis japonica, together with 13 known compounds. Their structures were determined through in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, celahin C and salasol A exhibited potent in vitro antituberculosis activity, both with an MIC value of 15.0 microg/ml against Mycobacterium tuberculosis H(37)Rv.

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A New Sesquiterpene Ester from Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells

Cited by 58 publications

References 9 publications

Isolation and Characterization of Sesquiterpenes from Celastrus orbiculatus and Their Antifungal Activities against Phytopathogenic Fungi

Isolation and Characterization of Sesquiterpenes from Celastrus orbiculatus and Their Antifungal Activities against Phytopathogenic Fungi

New Dihydroagarofuranoid Sesquiterpenes from Celastrus paniculatus

A New Dihydroagarofuranoid Sesquiterpene and Antituberculosis Constituents from the Root of Microtropis japonica

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