A new sesquiterpene lactone from the roots of Saussurea lappa: Structure–anticancer activity study

Robinson, A.; Kumar, Tanya; Sreedhar, Eppakayala; Naidu, V.G.M.; Krishna, Sistla Rama; Babu, K. Suresh; Srinivas, P.; Rao, J. Madhusudana

doi:10.1016/j.bmcl.2008.06.008

Cited by 90 publications

(42 citation statements)

References 18 publications

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“…A further interesting feature of plants of the Solanaceae family is that they produce a distinctive collection of sesquiterpenes described as the phytoalexins [14]. Previously dehydrocostus lactone (2) and costunolide (3) were reported to be isolated from Saussurea lappa Clarke (Compositae) [15], Cichorium intybus L. (Asteraceae) [16]. On the other hand the occurrence of catechin (4) in the title plant is in agreement with similar types of compounds previously reported from other Lycium species i.e from L. chinens [17].…”

Section: Chemotaxonomic Significancementioning

confidence: 99%

Chemical Constituents Isolated from Lycium shawii and their Chemotaxonomic Significance

Rehman¹,

Hussain²,

Al-Riyami³

et al. 2018

Rec.Nat.Prod.

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Phytochemical investigation of Lycium shawii Roem. & Schult provided fourteen compounds, including lyciumate (1), dehydrocostus lactone (2), costunolide (3), catechin (4), lyciumaside (5), emodin (6), (11), nonacosane-10-ol (12), betulinic acid (13) and β-sitosterol glucopyranoside (14). The compounds may be classified as three sesquiterpene lactones (1-3), two phenolic compounds (4 and 5), six anthraquinones (6-11), one long chain alcohol (12), one lupane-type triterpenoid (13) and a steroid (14). Compounds 2, 3, 7 and 9-12 are reported here for the first time as isolated from any species of Lycium as well as from the Solanaceae family while compounds 8, 13 and 14 are reported to be found for the first time in the genus Lycium. All structural assignments were made by comparing the NMR spectral data of the pure isolates with that published in the quoted literature.

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Section: Chemotaxonomic Significancementioning

confidence: 99%

Chemical Constituents Isolated from Lycium shawii and their Chemotaxonomic Significance

Rehman¹,

Hussain²,

Al-Riyami³

et al. 2018

Rec.Nat.Prod.

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“…although surgery is important in the initial therapy of patients with breast or ovarian cancer, most patients require chemotherapy to eliminate any residual microscopic or macroscopic peritoneal implants. Human ovarian cancer cell lines appear to be sensitive to dehydrocostuslactone, suggesting it has anticancer activity (11)(12)(13).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of anticancer activity of dehydrocostuslactone in vitro

Choi¹

2009

Mol Med Rep

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Abstract. dehydrocostuslactone is a sesquiterpene lactone derived from Saussurea lappa, a plant used in traditional herbal medicines. The anti-proliferative activity of dehydrocostuslactone was investigated in human breast cancer (Mda-MB-231, Mda-MB-453 and SK-Br-3) and ovarian cancer (SK-oV-3 and oVcar3) cell lines using the methyl thiazolyl tetrazolium assay. in the cells, exposure to dehydrocostuslactone resulted in a dose-dependent decline in cell proliferation. The ic 50 value was found to be 21.5, 43.2, 25.6, 15.9 and 10.8 µM in Mda-MB-231, Mda-MB-453, SK-Br-3, SK-oV-3 and oVcar3 cells, respectively. dehydrocostuslactone exerted its antiproliferative effects by inducing cell cycle arrest and apoptosis. cell cycle distribution and apoptosis were analyzed using flow cytometry in cell lines exposed to 10 µM dehydrocostuslactone for 48 h. compared to the controls, exposure to dehydrocostuslactone resulted in accumulation in the G2/M phase and a marked increase in the apoptotic cell population. These results suggest that dehydrocostuslactone has potential anticancer properties.

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“…Previous studies have showed that some plant extracts with pronounced cytotoxic in vitro had marked effects in vivo and showed promising potential to be used as an anticancer drugs. Indeed, sesquiterpene lactones, isolated from Carpesium rosulatum, have recently been largely studied for their pharmacological proprieties as anti-neoplastic agents (Ma G, 2009;Moon, 2011;Robinson, 2008;Taylor, 2008). Sesquiterpenes lactones, artemisinin, thapsigargin and parthenolide and many of their synthetic derivatives, are in advanced stage for clinical trials (Ghantous, 2010).…”

Section: Measurement Of Ros Productionmentioning

confidence: 99%

Antiproliferative Effect and Induction of Apoptosis by Inula viscosa L. and Retama monosperma L. Extracts in Human Cervical Cancer Cells

Merghoub

Benbacer²,

Btaouri³

et al. 2012

Topics on Cervical Cancer With an Advocacy for Prevention

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A new sesquiterpene lactone from the roots of Saussurea lappa: Structure–anticancer activity study

Cited by 90 publications

References 18 publications

Chemical Constituents Isolated from Lycium shawii and their Chemotaxonomic Significance

Chemical Constituents Isolated from Lycium shawii and their Chemotaxonomic Significance

Evaluation of anticancer activity of dehydrocostuslactone in vitro

Antiproliferative Effect and Induction of Apoptosis by Inula viscosa L. and Retama monosperma L. Extracts in Human Cervical Cancer Cells

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