A new spectrophotometric method for the determination of fluvoxamine maleate in pure form and in pharmaceutical formulation

Abstract

A simple, accurate and highly sensitive spectrophotometric methods are proposed for the rapid and accurate determination of fluvoxamine maleate (FXA) using bromocressol green (BCG), methyl orange (MO) and bromothymol blue (BTB). The developed methods involve formation of stable yellow colored chloroform extractable ion-associate complexes of the amino derivative (basic nitrogen) of the FXA with three sulphonphthalein acid dyes, namely; BCG, MO and BTB, in potassium hydrogen phthalate buffer pH 3.3, 3.6 and 3.4 respectively. The ion-associates exhibit absorption maxima at 420, 420 and 410 nm for BCG, MO and BTB, respectively. FXA can be determined up to 2.0-16, 2.0-15 and 2.0-20 µgmL −1 for BCG, MO and BTB, respectively. The effect of optimum conditions via pH on the ion pair formation, reagent concentration, time and temperature, and solvent was studied. The composition of the ion pairs was found 1:1 by Job's method. The low relative standard deviation values indicate good precision and high recovery values. These methods have been successfully applied for the assay of FXA in pure form and in pharmaceutical formulations and the results are in good agreement with those obtained by the official method.

A facile on–off fluorescence approach for fluvoxamine determination in pharmaceutical tablets; application to content uniformity testing

“…Reviewing the literature shows that there are numerous approaches for determining the medication under investigation. These strategies include: spectrophotometry, 3–6 spectrofluorimetry, 7–12 liquid chromatography (HPLC), 13–18 gas chromatography (GC), 19 thin layer chromatography, 20–22 electrochemical methods, 23–25 and capillary electrophoresis. 26 HPLC necessitates the use of expensive instruments and huge quantities of highly pure liquids.…”

Cost-Effective Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) and Based on Imprinted Receptors for Fluvoxamine Assessment

“…It harms a person's behavior and their social consequences in terms of reduced employment and psychosocial impairment. Postpartum depression Many different analytical techniques have been developed and reported for FLV quantification, such as high performance liquid chromatography (HPLC)coupled with either fluorescence [8,9] or ultra-violet (UV) detectors [10][11][12][13][14][15][16], gas chromatography/mass detection (GC/MS) [17], gas chromatography/flame ionization detection (FID) [18], capillary electrophoresis [19][20][21], fluorimetry [22], flow-injection chemiluminescence (FI-CL) [23,24], electrochemical methods [25][26][27] and spectrophotometry [28][29][30]. Most of these techniques required prior derivatization or extraction steps and involve using expensive equipment and chemicals.…”

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“…[3] Research works were performed for analytical method development for fluvoxamine using HPLC [4] and UV method. [5] The quality control dissolution procedure is used to the completeness of drug release from batch to batch, evaluated with regular conventional buffer with or without surfactant,…”