A new strategy for the preparation of total iridoids from Radix Gentianae Macrophyllae and anti-inflammatory profile digesting by UPLC-Q-TOF-MS characterization coupled with PLS analysis

Liu, Huan; Zhao, Huan; Hu, Wenyi; Hu, Hai-Min; Hou, Shu-Bing; Chen, Guang

doi:10.1016/j.indcrop.2021.113586

Cited by 8 publications

(3 citation statements)

References 39 publications

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“…Iridoid, a herbal ingredient of G. macrophylla Pall., and Quercetin and Icariin, ingredients of E. brevicornu Maxim. , are known to have anti-inflammatory effects by inhibiting the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in macrophages ( Liu et al, 2021 ; Zhang et al, 2022 ). Therefore, it is presumed that this mechanism influenced the results of this study.…”

Section: Discussionmentioning

confidence: 99%

Combination effects of herbal and western medicines on osteoporosis in rheumatoid arthritis: systematic review and meta-analysis

Kwon

et al. 2023

Front. Pharmacol.

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Purpose: This study aimed to comprehensively review the effect of combining herbal medicine (HM) with Western Medicine (WM) compared to WM alone on bone mineral density (BMD) improvement for osteoporosis in patients with rheumatoid arthritis (RA).Methods: Randomized controlled trials (RCTs) were searched using 10 databases, including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and Nation Information by NII. We selected studies that used BMD as an evaluation index and administered HM treatment for osteoporosis in patients with RA. Subsequently, a meta-analysis was conducted using BMD as a continuous variable using RevMan version 5.4.Results: Eighteen RCTs that met the eligibility criteria of this study were selected. The total number of study participants was 1,491 (481 men and 1,010 women). The mean age of participants was 52.4 ± 7.4 years, and the mean morbidity period of RA was 6.8 ± 1.3 years. In all studies, disease-modifying anti-rheumatic drugs (DMARDs; 16 RCTs) or bisphosphonates (two RCTs) were used as WM co-intervention with HMs (17 types of HM, 18 RCTs). Overall, the combination of HM and WM improved the BMD score, producing better results than WM alone. In particular, when HM was used in combination with DMARDs, which were used in most studies, BMD improved by 0.04 g/cm2 (95% confidence interval [CI]: 0.03–0.05, p < 0.001, I2 = 19%) in the lumbar spine and 0.03 g/cm2 (95% CI: 0.02–0.03, p < 0.001, I2 = 0%) in the femoral neck compared to the DMARDs alone group after treatment. In addition to BMD, bone markers and inflammatory indicators evaluated by each RCT showed significant improvement after HM plus WM treatment. In the analysis of frequently prescribed HMs, the BMD after treatment was higher by 0.04 g/cm2 (95% CI: 0.03–0.04, p < 0.001, I2 = 45%) in the Xianlinggubao-capsule plus methotrexate (MTX) group and by 0.02 g/cm2 (95% CI: 0.00–0.03, p = 0.04, I2 = 0) in the Hanbikang-tang plus MTX group compared to the MTX alone group.Conclusion: This systematic review cautiously provides evidence for the combined therapeutic effect of HM and WM for osteoporosis in patients with RA. However, well-designed, large-scale clinical trials are necessary before recommending this combination therapy for osteoporosis in patients with RA.Systematic Review Registration: [https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=331854], identifier [CRD42022331854].

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Section: Discussionmentioning

confidence: 99%

Combination effects of herbal and western medicines on osteoporosis in rheumatoid arthritis: systematic review and meta-analysis

Kwon

et al. 2023

Front. Pharmacol.

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“…The EUFE was prepared according to the method reported by Liu et al 13 Briefly, the fresh male flowers of E. ulmoides were collected from Zhangjiajie, Hunan Province, China and dried to achieve a moisture content of less than 10%. The pulverized male flowers (80 mesh size) were then extracted three times using a 70% ethanol aqueous solution at a solvent/material ratio (20 mL g −1 ) for 120 min.…”

Section: Methodsmentioning

confidence: 99%

Asperuloside, the bioactive compound in the edible Eucommia ulmoides male flower, delays muscle aging by daf-16 mediated improvement in mitochondrial dysfunction

et al. 2023

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“…The procedure was performed following the previously described reference with some modifications ( Liu et al, 2021 ). Originally, HepG2 cells were cultured in a petri dish (60 mm × 15 mm) treated with the control group, IR model group, MET group and different concentrations of RPEFs groups.…”

Section: Methodsmentioning

confidence: 99%

Efficient purification of flavonoids from bamboo shoot residues of Phyllostachys edulis by macroporous resin and their hypoglycemic activity

et al. 2022

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A new strategy for the preparation of total iridoids from Radix Gentianae Macrophyllae and anti-inflammatory profile digesting by UPLC-Q-TOF-MS characterization coupled with PLS analysis

Cited by 8 publications

References 39 publications

Combination effects of herbal and western medicines on osteoporosis in rheumatoid arthritis: systematic review and meta-analysis

Combination effects of herbal and western medicines on osteoporosis in rheumatoid arthritis: systematic review and meta-analysis

Asperuloside, the bioactive compound in the edible Eucommia ulmoides male flower, delays muscle aging by daf-16 mediated improvement in mitochondrial dysfunction

Efficient purification of flavonoids from bamboo shoot residues of Phyllostachys edulis by macroporous resin and their hypoglycemic activity

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