A New Strategy for the Rapid Identification and Validation of the Direct Targets of Aconitine-Induced Cardiotoxicity

Wei, Jinxia; Fan, Simiao; Yu, Hongxin; Shu, Lexin; Li, Yubo

doi:10.2147/dddt.s335461

Cited by 11 publications

(5 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study was performed following the previous report. 41 The docking results were used to rank the Pt II complex, and the best pose was collected for further analysis.…”

Section: Methodsmentioning

confidence: 99%

Antitumor effects of new glycoconjugated Pt^II agents dual-targeting GLUT1 and Pgp proteins

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The study was performed following the previous report. 41 The docking results were used to rank the Pt II complex, and the best pose was collected for further analysis.…”

Section: Methodsmentioning

confidence: 99%

Antitumor effects of new glycoconjugated Pt^II agents dual-targeting GLUT1 and Pgp proteins

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Hence, there is a growing sense of vigilance regarding the medical application of prescriptions or herbal remedies containing AC. Nevertheless, the ongoing misapplication of herbal medicines containing AC has led to further instances of acute or long-term cardiac toxicity ( Wei et al, 2021 ). According to previous research, a considerable percentage of individuals (around 90%) who suffer from AC poisoning have shown various types of polymorphic ventricular arrhythmias, including ventricular premature beats, ventricular rapid heartbeat and ventricular flutter ( Yu et al, 2015 ).…”

Section: Pharmacological Activities Of Acmentioning

confidence: 99%

Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms

Zhao,

Tian,

Geng

et al. 2024

Front. Chem.

View full text Add to dashboard Cite

Aconitine (AC), which is the primary bioactive diterpene alkaloid derived from Aconitum L plants, have attracted considerable interest due to its unique structural feature. Additionally, AC demonstrates a range of biological activities, such as its ability to enhance cardiac function, inhibit tumor growth, reduce inflammation, and provide analgesic effects. However, the structure-activity relationships of AC are remain unclear. A clear understanding of these relationships is indeed critical in developing effective biomedical applications with AC. In line with these challenges, this paper summarized the structural characteristics of AC and relevant functional and bioactive properties and the structure-activity relationships presented in biomedical applications. The primary temporal scope of this review was established as the period spanning from 2010 to 2023. Subsequently, the objective of this review was to provide a comprehensive understanding of the specific action mechanism of AC, while also exploring potential novel applications of AC derivatives in the biomedical field, drawing upon their structural characteristics. In conclusion, this review has provided a comprehensive analysis of the challenges and prospects associated with AC in the elucidation of structure-bioactivity relationships. Furthermore, the importance of exploring modern biotechnology approaches to enhance the potential biomedical applications of AC has been emphasized.

show abstract

“…Aconitine is an active compound derived from Aconitum species, highly toxic to the heart. Therefore, early intervention and treatment must be carried out for the cardiotoxicity caused by aconitine (Wei et al, 2021). Liquiritin could reduce the release of LDH, inhibit the mRNA expression of Cavl.2 and Kv4.3 in rat cardiomyocytes induced by aconitine, and reduce the toxic effects of aconitine (Dong et al, 2009).…”

Section: Aconitine-induced Cardiotoxicitymentioning

confidence: 99%

Liquiritin: A natural flavonoid with potential cardiovascular protection

Zhou,

Peng,

Zhou

2024

Ital. J. Food Sci.

View full text Add to dashboard Cite

Liquiritin is a flavonoid glycoside extracted from traditional Chinese medicine, Radix et Rhizoma Glycyrrhizae. The provide evidence has found that liquiritin has been found to be beneficial to cardiovascular disease. Inflammation and oxidation play key roles in cardiovascular diseases. In this review, the natural sources, biosynthesis, pharmacology and molecular docking of liquiritin were reviewed for the first time. Additionally, we have highlighted the target prediction of liquiritin. Docking results displayed that the three targets with the largest difference in VINA scores were TLR4, Keap-1 and AMPK, which suggested that liquiritin was likely to act on TLR4, Keap-1 and AMPK. Liquiritin will provide theoretical basis for future development and research in cardiovascular diseases.

show abstract

A New Strategy for the Rapid Identification and Validation of the Direct Targets of Aconitine-Induced Cardiotoxicity

Cited by 11 publications

References 46 publications

Antitumor effects of new glycoconjugated Pt^II agents dual-targeting GLUT1 and Pgp proteins

Antitumor effects of new glycoconjugated Pt^II agents dual-targeting GLUT1 and Pgp proteins

Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms

Liquiritin: A natural flavonoid with potential cardiovascular protection

Contact Info

Product

Resources

About

A New Strategy for the Rapid Identification and Validation of the Direct Targets of Aconitine-Induced Cardiotoxicity

Cited by 11 publications

References 46 publications

Antitumor effects of new glycoconjugated PtII agents dual-targeting GLUT1 and Pgp proteins

Antitumor effects of new glycoconjugated PtII agents dual-targeting GLUT1 and Pgp proteins

Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms

Liquiritin: A natural flavonoid with potential cardiovascular protection

Contact Info

Product

Resources

About

Antitumor effects of new glycoconjugated Pt^II agents dual-targeting GLUT1 and Pgp proteins

Antitumor effects of new glycoconjugated Pt^II agents dual-targeting GLUT1 and Pgp proteins