A new study on Omeprazole spectrophotometric determination using 9- Fluorenylmethyl chloroformate as derivatizating agent

Abstract

All reagents and chemicals are with analytical grade, distilled water was used in all experiments. Stock standard solution OMZ stock powder (99.9%) was obtained kindly from Amipharma Laboratories (Sudan), 100µg/mL solution of OMZ in acetonitrile

An amplified electrochemical sensor employing one-step synthesized nickel–copper–zinc ferrite/carboxymethyl cellulose/graphene oxide nanosheets composite for sensitive analysis of omeprazole

“…4–6 In fact, OMP is a pro-drug that is converted to an active sulfenamide intermediate at low pHs that binds to the thiol groups of the gastric wall proton pump cell (H + /K + -ATPase). 3,7,8 Due to the importance of measuring OMP as well as the widespread commercialization of OMP-containing drug formulations, a wide range of analytical techniques including spectrophotometric, 7,9–11 electrophoretic, 8,12 chromatographic 13–17 and electroanalytical methods 18–23 have been reported to its evaluation. Spectroscopic and chromatographic methods to measure the OMP often require complicated and tedious sample preparation, pretreatment processes, expensive materials, and advanced instruments.…”