A new targeted delivery approach by functionalizing drug nanocrystals through polydopamine coating

Zhan, Honglei; Jagtiani, Tina; Liang, Jun

doi:10.1016/j.ejpb.2017.01.020

Cited by 34 publications

(17 citation statements)

References 42 publications

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“…More importantly, the PDA coating is able to provide a platform for secondary reactions via Schiff base or Michael additions for diverse functional applications like reduction of noble metal ions to metal nanoparticles or binding of bioactive peptides. We have proven that such PDA-coated CPT can be easily decorated by ligands to demonstrate extreme anticancer activity.…”

Section: Resultsmentioning

confidence: 99%

Self-Polymerization of Dopamine in Acidic Environments without Oxygen

et al. 2017

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An alkaline environment and the presence of oxygen are essential requirements for dopamine polymerization. In this study, we are the first to demonstrate the self-polymerization of dopamine through plasma-activated water (PAW) under acidic environments (pH < 5.5). Resulting poly(dopamine) (PDA) was characterized using Nanosizer, SEM, FTIR, UV-vis, H NMR, and fluorescence spectrophotometers and proved to have similar physical and chemical properties to those polymerized under a basic condition, except that the PDA particles formed in PAW were more stable and hardly aggregated at varied pHs. The PAW polymerization method avoids alkaline solutions and the presence of oxygen and thus extends the applications of dopamine polymerization, particularly in biomedical and pharmaceutical sciences.

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Section: Resultsmentioning

confidence: 99%

Self-Polymerization of Dopamine in Acidic Environments without Oxygen

et al. 2017

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“…Although CPT nanocrystals demonstrated considerable advantages in the field of cancer treatment, their further clinical applications were still hampered. Since pure CPT nanocrystals lacked active targeting accuracy, they still displayed low bioavailability, limited therapeutic efficacy, and severe side effects. − Consequently, more elaborated active tumor targeting strategy, for example, based on the ligand and receptors overexpressed on surface of cancer cells, should be designed and adopted, to enhance the specific delivery and internalization of drugs by cancer cells. − …”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid-Coated Camptothecin Nanocrystals for Targeted Drug Delivery to Enhance Anticancer Efficacy

Wang

Muhammad

et al. 2020

Mol. Pharmaceutics

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Tumor-targeted drug delivery via chemotherapy is very effective on cancer treatment. For potential anticancer agent such as Camptothecin (CPT), high chemotherapeutic efficacy and accurate tumor targeting are equally crucial. Inspired by special CD44 binding capability from hyaluronic acid (HA), in this study, novel HA-coated CPT nanocrystals were successfully prepared by an antisolvent precipitation method for tumor-targeted delivery of hydrophobic drug CPT. These HA-coated CPT nanocrystals demonstrated high drug loading efficiency, improved aqueous dispersion, prolonged circulation, and enhanced stability resulting from their nanoscaled sizes and hydrophilic HA layer. Moreover, as compared to crude CPT and naked CPT nanocrystals, HA-coated CPT nanocrystals displayed dramatically enhanced in vitro anticancer activity, apoptosis-inducing potency against CD44 overexpressed cancer cells, and lower toxic effect toward normal cells due to pH-responsive drug release behavior and specific HA-CD44 mediated endocytosis. Additionally, HA-coated CPT nanocrystals performed fairly better antimigration activity and biocompatibility. The possible molecular mechanism regarding this novel drug formulation might be linked to intrinsic mitochondria-mediated apoptosis by an increase of Bax to Bcl-2 ratio and upregulation of P53. Consequently, HA-coated CPT nanocrystals are expected to be an effective nanoplatform in drug delivery for cancer therapy.

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“…Since the pioneer work of Messersmith’s group [19], this property of PDA attracted increasing interest for its good biocompatibility and capability of forming of nanostructures [20,21] or their surface functionalization [22,23]. Liang et al recently reported the promising performance of tumor-targeting modified PDA-coated camptothecin nanocrystals [24].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Delivery of Imatinib into Vaginal Mucosa via a New Positively Charged Nanocrystal-Loaded in Situ Hydrogel Formulation for Treatment of Cervical Cancer

Huang

et al. 2019

Pharmaceutics

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The present study was carried out to investigate the potential of cationic functionalization on imatinib nanocrystals to improve the mucoadhesiveness and, thus, delivery to the lesion of cervicovaginal tumors. Amino-group-functionalized imatinib nanocrystals (NC@PDA-NH2) were prepared with near-spheroid shape, nanoscale size distribution, positive zeta potential, and relatively high drug content with the aid of the polydopamine-coating technique. Efficient interaction between NC@PDA-NH2 and mucin was proven by mucin adsorption which was related to the positive zeta-potential value of NC@PDA-NH2 and the change in the size distribution on mixing of NC@PDA-NH2 and mucin. Cellular uptake, growth inhibition, and apoptosis induction in cervicovaginal cancer-related cells demonstrated the superiority of NC@PDA-NH2 over unmodified nanocrystals. For practical intravaginal administration, NC@PDA-NH2 was dispersed in Pluronic F127-based thermosensitive in situ hydrogel, which showed suitable gelation temperature and sustained-release profiles. In comparison with unmodified nanocrystals, NC@PDA-NH2 exhibited extended residence on ex vivo murine vaginal mucosa, prolonged in vivo intravaginal residence, and enhanced inhibition on the growth of murine orthotopic cervicovaginal model tumors indicated by smaller tumor size, longer median survival time, and more intratumor apoptosis with negligible mucosal toxicity. In conclusion, cationic functionalization endowed NC@PDA-NH2 significant mucoadhesiveness and, thus, good potential against cervicovaginal cancer via intravaginal administration.

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A new targeted delivery approach by functionalizing drug nanocrystals through polydopamine coating

Cited by 34 publications

References 42 publications

Self-Polymerization of Dopamine in Acidic Environments without Oxygen

Self-Polymerization of Dopamine in Acidic Environments without Oxygen

Hyaluronic Acid-Coated Camptothecin Nanocrystals for Targeted Drug Delivery to Enhance Anticancer Efficacy

Enhanced Delivery of Imatinib into Vaginal Mucosa via a New Positively Charged Nanocrystal-Loaded in Situ Hydrogel Formulation for Treatment of Cervical Cancer

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