A new technique for evaluating heel xerosis grade and the effects of moisturizer on heel skin dryness

Choi, Joo Hee; Kim, E. J.; Jang, Seongman; Kim, A. R.; Lee, T. J.; Lee, H. K.

doi:10.1111/srt.12466

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…Increased TEWL leads to activation of serine proteases such as SC chymotryptic enzymes by increasing the pH on the skin surface [17]. Increased TEWL is also correlated with xerosis [18]. In the present study, senile pruritus patients had higher TEWL values than control subjects, and TEWL value was positively correlated with pruritus severity score (data not shown).…”

Section: Discussionmentioning

confidence: 43%

Lipidomics profiling of skin surface lipids in senile pruritus

Liu

Zhao

et al. 2020

Lipids Health Dis

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Background: Senile pruritus is common, yet its etiology remains unknown. Aging-associated skin barrier defects and skin surface lipid (SSL) alterations have been postulated to play important roles in its occurrence. In the present study, the lipidomic profiles of SSLs in elderly patients were examined to better understand the potential causes of senile pruritus. Methods: Transepidermal water loss (TEWL) was evaluated to assess the skin barrier function. The Ameliorated Kawashima Itch Scale score was used to measure the pruritus severity. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and multivariate data analysis were employed to investigate SSL alterations. Results: The results showed that senile pruritus patients had higher TEWL values than control subjects (13.13 ± 4.28 versus 6.71 ± 2.45, p < 0.01). LC-MS/MS revealed significant differences in the lipidomic profiles and identified 81 species of SSLs that differed between the two groups. Compared with control subjects, senile pruritus patients had increased levels of ceramides (Cers), diacylglycerols, fatty acids, phosphatidylcholines, phosphatidylethanolamines, phytosphingosines, sphingosines, diacylceryl-3-O-carboxyhydroxymethylcholine, diacylglyceryl trimethylhomoserine, and unsaturated free fatty acids, but decreased levels of triacylglycerol. Cer-EOS, Cer-NDS, and Cer-NS were positively correlated with TEWL value (p < 0.05). Pruritus severity score was positively correlated with sphingomyelin, Cer-NP, Cer-AS, Cer-NDS, and Cer-NS, but negatively correlated with Cer-BS, Cer-EODS, Cer-EOS, and Cer-AP. Conclusions: The present study indicated that patients with senile pruritus have impaired skin barrier function and altered SSL composition. Certain SSL species identified in this study may be potential targets for future studies on the pathogenesis of senile pruritus.

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Section: Discussionmentioning

confidence: 43%

Lipidomics profiling of skin surface lipids in senile pruritus

Liu

Zhao

et al. 2020

Lipids Health Dis

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“…TEWL leads to activation of serine proteases such as SC chymotryptic enzyme by increasing the pH on the skin surface (15). TEWL is also correlated to xerosis (16). In the current study, we found that the senile pruritus has a higher value of TEWL compared to that in controls, and the value of TEWL is positively correlated to the score of pruritus severity (data not shown).…”

Section: Correlation Of Ssl Alteration and Itch Severity In The Idiopmentioning

confidence: 41%

Lipidomics Profiling of Skin Surface Lipids in Senile Pruritus

Liu

Zhao

et al. 2020

Preprint

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Background: Senile pruritus is common, yet its etiology remains unknown. We examined the lipidomics profiles of skin surface lipids (SSL) in the elderly to better understand potential causes for senile pruritus. Methods:Transepidermal water loss (TEWL) was used to assess skin barrier function. Ameliorated Kawashima itch scale were used to measure the pruritus score. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and multivariate data analysis were used to investigate SSL alternations. Results:The results showed that the senile pruritus have higher TEWL values than controls (13.13±4.28 versus 6.71±2.45, p< 0.01). LC-MS/MS showed significant differences in lipidomics and identified 81 species of SSL that differ between two groups. Compared to controls, the levels of ceramides, diacylcerols, fatty acids, phosphatidylcholines, phosphatidylethar, phytosphingsines, sphingosines, diacylceryl-3-O-carboxyhydroxymethylcholine, diacylglyceryl trimethylhomoserine, unsaturated free fatty acids increased, whereas triacylglycerol decreased. CER-EOS, CER-NDS and CER-NS were positively correlated with TEWL values (p<0.05). Sphingomyelin, Cer-NP, Cer-AS, Cer-NDS, Cer-NS were positively correlated with pruritus severity scores, while Cer-BS, Cer-EODS, Cer-EOS, Cer-AP were negatively correlated. Conclusion:Our study indicated that the senile pruritus have impaired skin barrier function and altered SSL composition. Select SSL species identified in this study may be potential target for future studies on the pathogenesis of idiopathic senile pruritus

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“…The skin trans epidermal water loss (TEWL) value and moisture content can be used as physiological indicators to re ect the skin barrier function. Previous studies reported that the increased TEWL and decreased hydration content were associated with skin xerosis [12]. Skin surface lipids (SSLs) are a mixture of sebaceous gland lipids and intercellular lipids located in the outer layer of epidermal cells [13].…”

Section: Introductionmentioning

confidence: 99%

Lipidomics profiling to reveal the restorative effect of moisturizer in OICD patients

Fan

Mao

Wang

et al. 2022

Preprint

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Background Occupational irritant contact dermatitis (OICD) usually manifests as impaired skin barrier function. The composition of the skin surface lipids (SSLs) determined the skin barrier function. This study aims to evaluate the repair effect of moisturizer on the skin barrier function of OICD patients and lipidomic tools were used to explore potential repair mechanisms. Methods A self-controlled study based on occupational shampoo workers was conducted in Zhengzhou, China, in December 2019. The study lasted 2 weeks in total, and subjects with OICD symptoms applied moisturizing cream during the study. Skin moisture content and trans epidermal water loss (TEWL) values were used as secondary indicators, and SSLs were used as main indicators to evaluate the recovery effect of subjects' skin barrier function after the intervention. Results After using moisturizer for 2 weeks, skin moisture increased significantly (p < 0.001), and TEWL decreased. A total of 635 SSLs were detected and classified into 5 main classes. The relative abundance of all lipids increased. Long-chain fatty acids, glycerolipids (mainly triglycerides), and cholesterol lipids were the major lipid species repaired after 1 week of intervention. Glycerophospholipids as the main lipid were repaired after 2 weeks of intervention. Conclusion Moisturizer could be used as an effective intervention to increase SSLs and repair skin barrier function to a certain extent in OICD patients. Trial registration: This study was reviewed and approved by Zhengzhou University's Life Science Ethics Review Committee and Registered in the Chinese Clinical Trial Registry (ID: ChiCTR2000034103). Informed consent from participants was obtained before enrollment.

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A new technique for evaluating heel xerosis grade and the effects of moisturizer on heel skin dryness

Cited by 8 publications

References 12 publications

Lipidomics profiling of skin surface lipids in senile pruritus

Lipidomics profiling of skin surface lipids in senile pruritus

Lipidomics Profiling of Skin Surface Lipids in Senile Pruritus

Lipidomics profiling to reveal the restorative effect of moisturizer in OICD patients

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