A new technique for the deposition of standard solutions in total reflection X-ray fluorescence spectrometry (TXRF) using pico-droplets generated by inkjet printers and its applicability for aerosol analysis with SR-TXRF

Fittschen, Ursula E. A.; Hauschild, Stephan; Amberger, Martin A.; Lammel, Gerhard; Streli, Christina; Förster, Stephan; Wobrauschek, P.; Jokubonis, C.; Pepponi, G.; Falkenberg, Gerald; Broekaert, J. A. C.

doi:10.1016/j.sab.2006.09.009

Cited by 45 publications

(27 citation statements)

References 15 publications

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“…Results. In this study, the authors used an HP DeskJet 500C inkjet printer to apply a picodroplet containing the internal standard (160 pg Cobalt) onto the collected aerosol following a procedure described previously [78]. Using this internal standard, the elemental concentrations for each size fraction were calculated from fundamental parameters [67].…”

Section: Characterization Of Atmospheric Aerosols Using Sr-txrf and Fmentioning

confidence: 99%

Synchrotron radiation-induced total reflection X-ray fluorescence analysis

Meirer

Singh

Pianetta

et al. 2010

TrAC Trends in Analytical Chemistry

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Synchrotron radiation-induced total reflection X-ray fluorescence (SR-TXRF) analysis is a high sensitive analytical technique that offers limits of detection in the femtogram range for most elements. Besides the analytical aspect, SR-TXRF is mainly used in combination with angle-dependent measurements and/or X-ray absorption near-edge structure (XANES) spectroscopy to gain additional information about the investigated sample. In this article, we briefly discuss the fundamentals of SR-TXRF and follow with several examples of recent research applying the above-mentioned combination of techniques to analytical problems arising from industrial applications and environmental research. ª

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Section: Characterization Of Atmospheric Aerosols Using Sr-txrf and Fmentioning

confidence: 99%

Synchrotron radiation-induced total reflection X-ray fluorescence analysis

Meirer

Singh

Pianetta

et al. 2010

TrAC Trends in Analytical Chemistry

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“…More recently, aerosols have been tailored for use in drug delivery (Jain et al 1998;Hauschild et al 2005), Raman spectroscopy of levitated droplets (Trunk et al 1994), maskless lithography for microelectromechanical system (MEMS) fabrication (Wang et al 2004), and as particle standards containing trace levels of molecules for ion mobility spectroscopy (Fletcher et al 2008) and trace levels of elements for X--ray fluorescence spectrometry and laser ablation inductively coupled plasma mass spectrometry (Fittschen et al 2006;Fittschen et al 2008). …”

Section: Historic and Current Methods For Producing Microparticlesmentioning

confidence: 99%

Statistical Data Analyses of Trace Chemical, Biochemical, and Physical Analytical Signatures

Udey

2013

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Analytical and bioanalytical chemistry measurement results are most meaningful when interpreted using rigorous statistical treatments of the data. The same data set may provide many dimensions of information depending on the questions asked through the applied statistical methods. Three principal projects illustrated the wealth of information gained through the application of statistical data analyses to diverse problems.Firstly, novel aerosol test particles containing DNA barcodes were developed for the accurate assessment of aerosol transport and fate in populated locations. Aerosols are central to human and environmental health, and understanding the properties of these aerosols that are pervasive in our lives is essential. Test particles composed of FDA--approved saccharide food additives were generated using both a modified inkjet printer and a commercial spray dryer.Univariate statistical methods were used to evaluate generated particle size--distributions during production optimization. Non--coding DNA templates were incorporated into the particles as unique particle identifiers, which yielded customized test particles detectable using highly specific quantitative real--time polymerase chain reaction (QRT--PCR) assays. These safe, customizable, and specifically detected aerosol test particles will provide vital experimental feedback for evaluating aerosol dispersion and transport models. The project culminated with a successful demonstration of the aerosol test particles in an atmospheric release test.Secondly, an original method for non--invasively analyzing the chemical profiles of latent fingerprint residues was developed in order to gain a new level of information from the most common type of forensic evidence. Passive solid--phase microextraction (SPME) headspace sampling collects both endogenous and exogenous volatile and semi--volatile compounds contained in the fingerprint residue while preserving the fingerprint for traditional analyses.The information--rich chemical profiles obtained from gas chromatography--mass spectrometry (GC--MS) analyses of the SPME samples were used to quantitatively compare fingerprint compounds both between subjects and over a time course of 30 days using multivariate statistical analyses.Finally, endogenous metabolite profiles of cancer cells treated with anti--cancer agents were analyzed using gas chromatography--and high performance liquid chromatography--mass spectrometry (GC--MS and HPLC--MS), and the resulting complex data sets were interrogated using univariate and multivariate statistical analyses (e.g. ANOVA, PCA, PLS--DA, OPLS--DA).Possible modes of cytotoxicity of cisplatin and taxol, two commonly used cancer therapeutics, in breast and lung cancer cells were elucidated using statistical methods for data reduction in order to focus on the cellular biochemical processes most affected by drug treatment.Understanding how successful therapeutics interact with cells leads to design of novel anti--cancer agents that are more targeted and effective, minimizing dose-...

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“…Experiments at Hasylab, Beamline L showed that 1 h sampling time was sufficient to get a reasonable signal-this will lead to detailed studies of air pollution. Fittschen et al 58 published a new technique for the deposition of standard solutions by inkjet printers and its applicability for aerosol analysis. Droplet sizes of 50-200 mm were achieved (which are smaller than the available synchrotron beam) and the authors reported an absolute calibration of the number of droplets versus measured Co intensity.…”

Section: Applicationsmentioning

confidence: 99%

Synchrotron radiation induced TXRF

Streli

Wobrauschek

Meirer

et al. 2008

J. Anal. At. Spectrom.

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The use of synchrotron radiation (SR) as an excitation source for total reflection X-ray fluorescence analysis (TXRF) offers several advantages over X-ray tube excitation. Detection limits in the fg range can be achieved with efficient excitation for low Z as well as high Z elements due to the features of synchrotron radiation and in particular the high brilliance in a wide spectral range and the linear polarization in the orbital plane. SR-TXRF is especially interesting for samples where only small sample masses are available. Lowest detection limits are typically achieved using multilayer monochromators since they exhibit a bandwidth of about 0.01 DE/E. Monochromators with smaller bandwidth like perfect crystals, reduce the intensity, but allow X-ray absorption spectroscopy (XAS) measurements in fluorescence mode for speciation and chemical characterisation at trace levels. SR-TXRF is performed at various synchrotron radiation facilities. An historical overview is presented and recent setups and applications as well as some critical aspects are reviewed.

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A new technique for the deposition of standard solutions in total reflection X-ray fluorescence spectrometry (TXRF) using pico-droplets generated by inkjet printers and its applicability for aerosol analysis with SR-TXRF

Cited by 45 publications

References 15 publications

Synchrotron radiation-induced total reflection X-ray fluorescence analysis

Synchrotron radiation-induced total reflection X-ray fluorescence analysis

Statistical Data Analyses of Trace Chemical, Biochemical, and Physical Analytical Signatures

Synchrotron radiation induced TXRF

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