A new technique for the preparation of ready-to-use macroaggregated albumin (MAA) kits to be labelled with 99mTc for lung scanning

Al-Janabi, M. A. A.; Yousif, Zainab; Kadim, A.H.M.; Al-Salem, A.M.

doi:10.1016/0020-708x(83)90050-9

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…For Tc-99m, in two studies [137,138] at most trace amounts of activity were detected in the thyroid, whereas in a third a transient absorption of 0.2% of the applied activity was found there. Even in this worst case, the total exposure of the thyroid is negligible; although it could be reduced still further by thyroid blockage, this does not appear to be necessary.…”

Section: Safety Aspects Of Tc-99m-maa Lung Perfusion Scintigraphymentioning

confidence: 89%

Ventilation/perfusion lung scintigraphy: what is still needed? A review considering technetium-99m-labeled macro-aggregates of albumin

et al. 2009

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Lung perfusion scintigraphy (LPS) with technetium-99m-labeled macro-aggregates of albumin (Tc-99m-MAA) is well established in the diagnostic of pulmonary embolism (PE). In the last decade, it was shown that single-photon emission computer tomography (SPECT) acquisition of LPS overcame static scintigraphy. Furthermore, there are rare indications for LPS, such as preoperative quantification of regional lung function prior to lung resection or transplantation, optimization of lung cancer radiation therapy, quantification of right-left shunt, planning of intra-arterial chemotherapy, and several rare indications in pediatrics. Moreover, LPS with Tc-99m-MAA is a safe method with low radiation exposure. PE can also be diagnosed by spiral computer tomography (CT), ultrasound, magnetic resonance angiography, or pulmonary angiography (PA, former gold standard). The present review considers all these methods, especially spiral CT, and compares them with LPS with respect to sensitivity and specificity and gives an overview of established and newer publications. It shows that LPS with Tc-99m-MAA represents a diagnostic method of continuing value for PE. In comparison with spiral CT and/or PA, LPS is not to be defeated as mentioned also by the most actual Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED) II reports. This applies in particular to chronic or recurring embolisms, whereas currently spiral CT may be of greater value for major or life-threatening embolisms. At present, LPS cannot be replaced by other methods in some applications, such as pediatrics or in the quantification of regional pulmonary function in a preoperative context or prior to radiation therapy. LPS still has a place in the diagnostics of PE and is irreplaceable in several rare indications as described earlier.

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Section: Safety Aspects Of Tc-99m-maa Lung Perfusion Scintigraphymentioning

confidence: 89%

Ventilation/perfusion lung scintigraphy: what is still needed? A review considering technetium-99m-labeled macro-aggregates of albumin

et al. 2009

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“…Compared to microspheres, MAA particles have a variable shape, a different size distribution (90% within 10 to 90 μm) with a lower mean size (15 μm versus 25–32 μm), and are injected in much smaller numbers ( Table 2 ) [ 3 , 18 , 19 , 20 ]. These differences can explain some discrepancy between the MAA and the microsphere biodistribution, especially the risk of increased shunt to the lungs with MAA.…”

Section: Maa Particles As a Surrogate To Radioactive Microspheres: Ph...mentioning

confidence: 99%

A Theranostic Approach in SIRT: Value of Pre-Therapy Imaging in Treatment Planning

Dabadie

Walrand

Lhommel

et al. 2022

JCM

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Selective internal radiation therapy (SIRT) is one of the treatment options for liver tumors. Microspheres labelled with a therapeutic radionuclide (90Y or 166Ho) are injected into the liver artery feeding the tumor(s), usually achieving a high tumor absorbed dose and a high tumor control rate. This treatment adopts a theranostic approach with a mandatory simulation phase, using a surrogate to radioactive microspheres (99mTc-macroaggregated albumin, MAA) or a scout dose of 166Ho microspheres, imaged by SPECT/CT. This pre-therapy imaging aims to evaluate the tumor targeting and detect potential contraindications to SIRT, i.e., digestive extrahepatic uptake or excessive lung shunt. Moreover, the absorbed doses to the tumor(s) and the healthy liver can be estimated and used for planning the therapeutic activity for SIRT optimization. The aim of this review is to evaluate the accuracy of this theranostic approach using pre-therapy imaging for simulating the biodistribution of the microspheres. This review synthesizes the recent publications demonstrating the advantages and limitations of pre-therapy imaging in SIRT, particularly for activity planning.

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“…Several improvments had been studied in the procedures for production of Sn-MAA lyophilized kit with suitable particle size distribution had been achieved [14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

A New Formulation of 99mTc-Macroagreggated Albumin (MAA) Freeze-dried Kit for Lungs Scintigraphy

Jabbar

Al-shami

Abdulkarim

2008

AJPS

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A new formulation of macro aggregated albumin (MAA) to be labeled with 99mTc was prepared by a simple and fast method. The suspension of macroagreggated albumin was prepared by diluting 0.4ml human serum albumin (200mg/ml) with normal saline (sterilized and pyrogen free) Concentratedhydrochloric acid was added to denature the protein and this step was followed by the addition of tin in the form of stannite . 3.5ml of polyethylene glycol(PEG) (1mg/ml) was also added to act as antiagglomerating agent. The pH was adjusted to 5.2 with NaOH and the suspension was heated with continuousstirring to get aggregation The vials contents were allowed to react with 99mTc and high radiochemical purity was obtained (greater than 95%) after 15min. 99mTc-MAA was stable for at least six hours.The organ distribution data in mice showed that more than 93.0% of the injected dose has accumulated in the lungs with a negligible amount of radioactivity to be detected in the non target organs.The size distribution data showed that 80.0% of the particles occur in the range of 10—80μm. The freeze-dried preparation of Sn-MAA kits (sterile and pyrogen free) were stable for at least 170 day.

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A new technique for the preparation of ready-to-use macroaggregated albumin (MAA) kits to be labelled with 99mTc for lung scanning

Cited by 7 publications

References 9 publications

Ventilation/perfusion lung scintigraphy: what is still needed? A review considering technetium-99m-labeled macro-aggregates of albumin

Ventilation/perfusion lung scintigraphy: what is still needed? A review considering technetium-99m-labeled macro-aggregates of albumin

A Theranostic Approach in SIRT: Value of Pre-Therapy Imaging in Treatment Planning

A New Formulation of 99mTc-Macroagreggated Albumin (MAA) Freeze-dried Kit for Lungs Scintigraphy

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