A new ternary copper(II) complex derived from 2-(2′-pyridyl)benzimidazole and glycylglycine: Synthesis, characterization, DNA binding and cleavage, antioxidation and HSA interaction

Fu, Xia-Bing; Lin, Zihua; Liu, Haifeng; Le, Xueyi

doi:10.1016/j.saa.2013.11.006

Cited by 71 publications

(23 citation statements)

References 47 publications

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“…was eliminated for the interaction studies due to its limited solubility in aqueous media under same conditions. The association of the compounds 2a and 2b with HSA exhibited similar effects and moderate binding constants by fluorimetric titration compared with the interactions studies in which the metal used complexes of benzimidazole derivatives with HSA (27,28). In the present study, the binding properties of 2a and 2b to HSA were investigated using spectroscopic methods.…”

Section: Introductionmentioning

confidence: 68%

“…These molecules exhibit anti-viral, anti-inflammatory, anti-tumor, analgesic, anti-pyretic, anti-ulcer and anti-bacterial properties, and drugs containing imidazo[1,2-a]pyridine ring such as zolpidem (hypnotic) are currently available on the market (22)(23)(24). The association of the compounds 2a and 2b with HSA exhibited similar effects and moderate binding constants by fluorimetric titration compared with the interactions studies in which the metal used complexes of benzimidazole derivatives with HSA (27,28). We prepared two dicationic styrylimidazo[1,2-a]pyridinium dyes, called 2a and 2b for this purpose (Scheme 1) (25,26).…”

Section: Introductionmentioning

confidence: 93%

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Investigation of binding properties of dicationic styrylimidazo[1,2‐a]pyridinium dyes to human serum albumin by spectroscopic techniques

et al. 2016

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The binding interaction between two dicationic styrylimidazo[1,2-a]pyridinium dyes and human serum albumin (HSA) was investigated at physiological conditions using fluorescence, UV-vis absorption, and circular dichroism (CD) spectroscopies. Analysis of the fluorescence titration data at different temperatures suggested that the fluorescence quenching mechanism of HSA by these dyes was static. The calculated thermodynamic parameters (ΔG°, ΔH° and ΔS°) indicated that hydrogen bonding and van der Waals forces played a major role in the formation of the dye-HSA complex. Binding distances (r) between dyes and HSA were calculated according to Förster's non-radiative energy transfer theory. Studies of conformational changes of HSA using CD measurements indicate that the α-helical content of the protein decreased upon binding of the dyes. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 93%

Investigation of binding properties of dicationic styrylimidazo[1,2‐a]pyridinium dyes to human serum albumin by spectroscopic techniques

et al. 2016

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“…CD spectroscopy is a useful and sensitive technique for monitoring conformational changes in pro-tein [5,11]. The CD spectrum of HSA contained two negative peaks in the ultraviolet region at 208 and 220 nm, which were both due to the n → π * transfer of the peptide bond of α-helix [4,28].…”

Section: Spectrum Studymentioning

confidence: 99%

“…The World Health Organization clearly stated that using oral contraceptives can contribute to protection against unintended pregnancies and Sexually Transmitted Infection, including HIV. Therefore, determining the interactions between norgestrel and HSA can aid research on the norgestrel's solubility in plasma, decreasing its toxicity, and preventing oxidation of the bound drug [11,12], which can influence pharmacological activity and pharmacokinetics.…”

Section: Introductionmentioning

confidence: 99%

Investigation on the Interaction of Norgestrel with Human Serum Albumin Using Spectroscopy and Molecular‐Docking Method

Wang

et al. 2016

J Biochem & Molecular Tox

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The interaction of norgestrel with human serum albumin (HSA) was investigated by spectroscopy and molecular-docking methods. Results of spectroscopy methods suggested that the quenching mechanism of norgestrel on HSA was static quenching and that the quenching process was spontaneous. Negative values of thermodynamic parameters (ΔG, ΔH, and ΔS) indicated that hydrogen bonding and van der Waals forces dominated the binding between norgestrel and HSA. Three-dimensional fluorescence spectrum and circular dichroism spectrum showed that the HSA structure was slightly changed by norgestrel. Norgestrel mainly bound with Sudlow site I based on a probe study, as confirmed by molecular-docking results. Competition among similar structures indicated that ethisterone and norethisterone affected the binding of norgestrel with HSA. CH3 in R1 had little effect on norgestrel binding with HSA. The surface hydrophobicity properties of HSA, investigated using 8-anilino-1-naphthalenesulfonic acid, was changed with norgestrel addition.

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“…76,192 Além disso, de acordo com a literatura as alterações conformacionais observadas na estrutura secundária da HSA resultam em um aumento na exposição de algumas regiões hidrofóbicas. 193,194 Como reportado anteriormente a ligação formada entre o complexos trinuclear e a proteína apresenta caráter hidrofóbico.…”

Section: Análise Conformacional Da Hsa Por Espectroscopia De Dicroísmunclassified

Complexos trinucleares de rutênio com ponte -oxo contendo ligantes N-heterocíclicos e monóxido de carbono: síntese, caracterização e estudo de interação com biomoléculas

Moreira¹

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AGRADECIMENTOSPrimeiramente agradeço à Prof. Dra. Sofia Nikolaou pela oportunidade de trabalhar em seu grupo, pela dedicação, atenção e pelos conhecimentos transmitidos. Sou e sempre serei grata por tudo que a professora me proporcionou neste tempo de aprendizado e amadurecimento científico.Ao Prof. Dr. Roberto Santana da Silva, pela amizade, pela confiança, pela acolhida em seu laboratório, pelas discussões científicas, pelas contribuições realizadas no exame de qualificação e pelo uso dos reagentes e equipamentos.Ao Prof. Gregóire Jean-François Demets, pelos conhecimentos transmitidos e pelas contribuições realizadas em meu exame de qualificação.Ao Prof. Dr. Elia Tfouni, pelos conhecimentos e materiais de fotoquímica.Ao Prof. Dr. Victor Marcelo Deflon (IQ-USP -São Carlos), pela colaboração na obtenção dos resultados de difração de raios-X. Aos meus irmãos queridos José Maria, Jú e Marta, por serem meu porto seguro, meu amparo em todos os momentos desde os meus primeiros passos, por acreditar em mim, pelo amor, carinho e apoio constante. Estendo a minha gratidão aos meus cunhados Sérgio Akira e Marili pelo apoio e carinho.Aos meus amáveis sobrinhos Daniel e Leandro, por tornar meus dias mais coloridos.Aos meus Pais, "pai e mãe ouro de mina", pelo amor puro e incondicional. Não há palavras exatas para demonstrar a minha gratidão por tudo que fizeram por mim.À minha filha Maria Carolina, por ser compreensiva, amorosa, leal e amiga em todos os momentos.A todos que colaboraram direta ou indiretamente com a realização deste trabalho.

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A new ternary copper(II) complex derived from 2-(2′-pyridyl)benzimidazole and glycylglycine: Synthesis, characterization, DNA binding and cleavage, antioxidation and HSA interaction

Cited by 71 publications

References 47 publications

Investigation of binding properties of dicationic styrylimidazo[1,2‐a]pyridinium dyes to human serum albumin by spectroscopic techniques

Investigation of binding properties of dicationic styrylimidazo[1,2‐a]pyridinium dyes to human serum albumin by spectroscopic techniques

Investigation on the Interaction of Norgestrel with Human Serum Albumin Using Spectroscopy and Molecular‐Docking Method

Complexos trinucleares de rutênio com ponte -oxo contendo ligantes N-heterocíclicos e monóxido de carbono: síntese, caracterização e estudo de interação com biomoléculas

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