A new terpene ketone, a component of the essential oil ofElsholtzia ciliata

Dembitskii, A. D.; Калинкина, Г. И.; Bergaliev, E. Sh.

doi:10.1007/bf00629641

Cited by 10 publications

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“…The major compounds of this essential oil were dehydroelsholzia ketone (78.28%) and elsholtzia ketone (14.58%) ( Supplementary Materials Table S1 ). The composition of this essential oil was similar to that reported by other groups [ 6 , 7 , 8 ], with the main component dehydroelsholtsia ketone, which was first isolated from this source in 1997, and for which a structure of 3-methyl-2-(3-methylbut-2-enoyl)furan was suggested [ 9 ]. Chemical composition of E. ciliata herb could vary because of environmental factors and different growing places [ 10 ].…”

Section: Introductionsupporting

confidence: 83%

Antiarrhythmic Properties of Elsholtzia ciliata Essential Oil on Electrical Activity of the Isolated Rabbit Heart and Preferential Inhibition of Sodium Conductance

et al. 2020

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Elsholtzia ciliata essential oil (E. ciliata) has been developed in Lithuania and internationally patented as exerting antiarrhythmic properties. Here we demonstrate the pharmacological effects of this herbal preparation on cardiac electrical activity. We used cardiac surface ECG and a combination of microelectrode and optical mapping techniques to track the action potentials (APs) in the Langendorff-perfused rabbit heart model during atrial/endo-/epi-cardial pacing. Activation time, conduction velocity and AP duration (APD) maps were constructed. E. ciliata increased the QRS duration and shortened QT interval of ECG at concentrations of 0.01–0.1 μL/mL, whereas 0.3 μL/mL (0.03%) concentration resulted in marked strengthening of changes. In addition, the E. ciliata in a concentration dependent manner reduced the AP upstroke dV/dtmax and AP amplitude as well as APD. A marked attenuation of the AP dV/dtmax and a slowing spread of electrical signals suggest the impaired functioning of Na+-channels, and the effect was use-dependent. Importantly, all these changes were at least partially reversible. Our results indicate that E. ciliata modulates cardiac electrical activity preferentially inhibiting Na+ conductance, which may contribute to its effects as a natural antiarrhythmic medicine.

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Section: Introductionsupporting

confidence: 83%

Antiarrhythmic Properties of Elsholtzia ciliata Essential Oil on Electrical Activity of the Isolated Rabbit Heart and Preferential Inhibition of Sodium Conductance

et al. 2020

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“…With respect to the content of that compound in the oil sample, it was possible to record 1D and 2D-NMR spectra (HSQC) and consequently to assign the chemical shifts of all protons and carbons. 1 H NMR: δ 7.39 (d, 1.1Hz, H-1 Dehydroelsholtzia ketone was proposed by the commercial MS library [15] and confirmed by comparison of the 13 C NMR spectroscopic data with those reported by Dembitskii et al for a compound isolated from the essential oil of Elsholtzia ciliata [21].…”

Section: Identification Of the Componentsmentioning

confidence: 66%

Combined Analysis by GC (RI), GC/MS and ¹³C NMR Spectroscopy of Elsholtzia blanda, E. penduliflora and E. winitiana Essential Oils

Lesueur

Bighelli

Tâm

et al. 2007

Natural Product Communications

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The chemical composition of six oil samples, isolated from aerial parts of Elsholtzia blanda, E. penduliflora and E. winitiana, harvested in two provinces of Vietnam, was investigated by GC, in combination with retention indices (RI), GC/MS and 13 C NMR spectroscopy. Linalool was the major component (75.2 and 56.8%) of the two samples of E. blanda essential oil, whereas the two oil samples from E. penduliflora were dominated by 1,8-cineole (62.7 and 65.5%). Conversely, the two oil samples of E. winitiana exhibited different compositions, rosefuran (56.0%) and dehydroelsholtzia ketone (22.8%) being the major components of one sample, whilst the second sample was dominated by elsholtzia ketone (87.5%).

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“…stauntonii , and E . ciliate are much more than on other species [45,51,52,55,56,61-63,67-78]. The identified volatile components from the genus are shown in Additional file 4: Table S3, associated with the corresponding plant sources.…”

Section: Reviewmentioning

confidence: 99%

Elsholtzia: phytochemistry and biological activities

Guo

Liu

Wang

et al. 2012

Chemistry Central Journal

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Plants of the genus Elsholtzia (Lamiaceae) have a long history of medicinal use in folk. The phytochemical investigations revealed the presence of flavonoids, phenylpropanoids, terpenoids, and other compounds. Abundant volatile components are also identified. Pure compounds, volatile constituents and crude extracts from the genus exhibited a wide spectrum of in vitro and in vivo pharmacological activities. The aims of this review hopefully provide comprehensive information on the distribution, phytochemistry, volatile components, and pharmacological research of Elsholtzia for exploring the potential and advance researches.

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A new terpene ketone, a component of the essential oil ofElsholtzia ciliata

Cited by 10 publications

References 0 publications

Antiarrhythmic Properties of Elsholtzia ciliata Essential Oil on Electrical Activity of the Isolated Rabbit Heart and Preferential Inhibition of Sodium Conductance

Antiarrhythmic Properties of Elsholtzia ciliata Essential Oil on Electrical Activity of the Isolated Rabbit Heart and Preferential Inhibition of Sodium Conductance

Combined Analysis by GC (RI), GC/MS and ¹³C NMR Spectroscopy of Elsholtzia blanda, E. penduliflora and E. winitiana Essential Oils

Elsholtzia: phytochemistry and biological activities

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A new terpene ketone, a component of the essential oil ofElsholtzia ciliata

Cited by 10 publications

References 0 publications

Antiarrhythmic Properties of Elsholtzia ciliata Essential Oil on Electrical Activity of the Isolated Rabbit Heart and Preferential Inhibition of Sodium Conductance

Antiarrhythmic Properties of Elsholtzia ciliata Essential Oil on Electrical Activity of the Isolated Rabbit Heart and Preferential Inhibition of Sodium Conductance

Combined Analysis by GC (RI), GC/MS and 13C NMR Spectroscopy of Elsholtzia blanda, E. penduliflora and E. winitiana Essential Oils

Elsholtzia: phytochemistry and biological activities

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Combined Analysis by GC (RI), GC/MS and ¹³C NMR Spectroscopy of Elsholtzia blanda, E. penduliflora and E. winitiana Essential Oils