A NEW TEST SHOWING ABNORMAL NET Na+ AND K+ FLUXES IN ERYTHROCYTES OF ESSENTIAL HYPERTENSIVE PATIENTS

Lipids of erythrocyte membrane and Na-K ATPase activity in normotensive adolescents with hypertension heredity.

“…The relationship between Na-K ATPase activity and hypertension has been investigated (Swarts et al, 1981;Walter, 1982;Wambach et al, 1982;Wocial et al, 1984), since Garay and Meyer (1979) published their observations and estimated the positive association between sodium-potassium cotransport and hypertension. Recently an inhibitor of Na-K ATPase was found in hypertensives, and low activity of Na-K ATPase points to a possible association with essential hypertension (Hamlyn et al, 1982;Hugues et al, 1984;MacGreygor et al, 1980 Doge et al (1963).…”

An approach to the explanation of cell membrane alteration in primary hypertension.

“…In later studies, these data were supplemented by characteristics of other transport systems, namely sodium-potassium cotransport 17 and lithium-sodium 18 and Na + -H +19 countertransport. This confirmed the initial conclusion about the increased permeability to univalent cations of the erythrocyte membrane in primary hypertension.…”

Age-related reduction in the number of rabbit erythrocyte Na, K-ATPase.

“…The alterations in the sodium pump activity in erythrocytes have been described in various diseases including essential hypertension (Garay and Meyer 1979;Takayama et al 1984 ;Postnov and Orlov 1985;Hilton 1986), obesity (De Luise et al 1980) and hyperthyroidism (Suzuki et al 1983). However, the studies on the donor age-related changes in human erythrocyte sodium pump activity have yielded conflicting results (Hokin-Neaverson et al 1977 ;Naylor et al 1977 ;Schmalzing et al 1981), and little is known about the effect of donor aging on animal erythrocyte sodium pump activity.…”