A new theranostic system for bone disorders: Functionalized folate-MDP hydroxyapatite nanoparticles with radiolabeled copper-64

Nanostructured system based on hydroxyapatite and curcumin: A promising candidate for osteosarcoma therapy

“…Since the functionalization process of HA nanoparticles with curcumin/APTES carried on a slightly acidic medium, an interaction between protonated amine groups from APTES moiety of the functionalizing molecule and the hydroxyapatite unit cell can occur from substitution in hydroxyl sites (Scheme 1), as suggested by Cipreste and colleagues when these authors studied the functionalization of hydroxyapatite nanoparticles with aminated folic acid [39].…”

“…HA has wide use in biomedical materials, such as in the production of scaffolds for tissue engineering [32,33], in the coating of metallic implants [34,35], in drug delivery and controlled release systems [36][37][38] and in cancer therapy and diagnosis [39][40][41]. Izadi and colleagues [42] developed a magneto-responsive nanocomposite for chemotherapy delivery.…”

“…HA structures present high stability and flexibility, allowing some transition metal or lanthanide cations to be added as dopants in the apatite crystal lattice [40]. The doping of nano-sized HA with gadolinium as well as the combination with natural anticancer pharmaceutics, are research areas deserving further exploration aiming the use as a theranostic system to promote the diagnosis and treatment of cancer simultaneously [39,45,46]. On the other hand, much attention has been also focused on the synergistic effect of chemotherapeutic drug combinations with natural products such as curcumin hold great promise for enhancing their anticancer efficacy [47][48][49].…”

The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

“…As reported previously, metastatic disease contributes to significant deterioration in the quality of life for many cancer patients, and bone metastases are the most frequent incident in advanced cancer, especially from breast and prostate cancer. , Metastatic bone cancer occurs due to the migration of cancer cells from the primary tumor that enters the bloodstream, followed by extravasation to the immune system leading to colonization in the bone (which is the third most frequent site of metastasis). − Bone metastatic cancer can cause catastrophic consequences for the patient, including bone pain, impaired mobility, and hemopoietic complications (i.e., spinal cord compression, pathologic bone fracture, bone marrow aplasia). − , Bone pain in patients is usually associated with mechanical pain resulting from the pressure of tumor tissue within the bone and loss of bone strength . Therefore, research on developing new strategies to tackle bone cancers should be conducted to reduce the incidence of bone metastases, palliate skeletal disease, and tackle primary bone tumors.…”

Tellurium/Vanadate Doped Hydroxyapatite Nano-Scaffold Carrier for Doxorubicin Colon Cancer Targeting

“…XPS is used to determine the elements of the composition and ensure the bonding within the composition [30]. Fig 2a shows the composition's survey scan, which shows the significant bands attributed to the elements O, P, V, Te, Ca, and N. The N 1s peak in the survey scan confirms the presence of the nitrogen-containing compounds DOX and CS [31,32]. This survey proves the uniform loading of DOX within HAP as well as the even substitution of Te and V ions within HAP and the uniform coating with chitosan.…”