A new triterpenoid from Alisma orientale and their antibacterial effect

Abstract

A new triterpenoid, named alisol Q 23-acetate, as well as fourteen known terpenes, alisol B 23-acetate (2), alisol B (3), alismol (4), 10-O-methyl-alismoxide (5), alismoxide (6), 11-deoxyalisol C (7), 13β,17β-epoxyalisol B 23-acetate (8), 4β,12-dihydroxyguaian-6,10-diene (9), alisol C 23-acetate (10), alisolide (11), 16β-methoxyalisol B monoacetate (12), alisol A (13), 16β-hydroxyalisol B 23-acetate (14), alisol A 24-acetate (15) were isolated from the rhizomes of Alisma orientale. The structures of compounds (1-15) were identified based on 1D and 2D NMR, including (1)H-(1)H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Among these isolates, antibacterial effect of compounds 2, 3, 10, and 15, major constituents of A. orientale was examined. The MIC values of compounds 2, 10, and 15 were 5-10 βg/mL against eight antibiotic resistant strains, which were lower than those from the positive controls (MICs of chloramphenicol and ampicillin were 5-80 μg/mL). Therefore, compounds 2, 10 and 15 exhibited the potent antibacterial activity.

Protective Effects of Alisol B 23-Acetate Via Farnesoid X Receptor-Mediated Regulation of Transporters and Enzymes in Estrogen-Induced Cholestatic Liver Injury in Mice

“…1. Many pharmacological studies have revealed that AB23A has several pharmacological activities, such as antihepatitis virus, anti-proliferative activity of cancer cell lines and antibacterial effects (12)(13)(14). Recently, we have demonstrated that AB23A has promotive effect on liver regeneration and protective effect through FXR activation in mice (15,16).…”

Qualitative and Quantitative Analysis of Major Triterpenoids in Alismatis Rhizoma by High Performance Liquid Chromatography/Diode-Array Detector/Quadrupole-Time-of-Flight Mass Spectrometry and Ultra-Performance Liquid Chromatography/Triple Quadrupole Mass Spectrometry

“…Most beneficial effects of AMR are attributed to the presence of protostane terpenoids, which are relatively abundant in this preparation. Previous studies have indicated that triterpenoids have diverse biological activities such as hypolipidemic [1], anti-proliferative activities [6], antibacterial [7], antiplasmodial [8], antioxidative [9] and anti-inflammatory bioactivities [10].…”

Guaiane-Type Sesquiterpenoids from Alismatis Rhizoma and Their Anti-inflammatory Activity

“…The EtOAc fraction was purified using various column chromatographies to yield twelve guaiane-type sesquiterpenoids (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”