A new type of cuprous-cysteamine sensitizers: Synthesis, optical properties and potential applications

Wang, Y.; Alkhaldi, Noura; Pandey, Nil Kanatha; Chudal, Lalit; Wang, L.Y.; Lin, Liangwu; Zhang, M.B.; Yong, Yijing; Amador, Eric; Huda, Muhammad N.; Chen, W.

doi:10.1016/j.mtphys.2021.100435

Cited by 14 publications

(7 citation statements)

References 70 publications

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“… 400 – 402 Among them, X-ray induced PDT has attracted much attention because of its unlimited tissue penetration ability. 398 , 403 – 406 Most recently, Chen et al reported Cu-Cy, Cu 3 Cl(SR) 2 (R = CH 2 CH 2 NH 2 ), 407 , 408 a new type of sensitizer, has strong luminescence 407 , 409 and can produce ROS under UV irradiation, 407 , 410 X-rays, 411 – 413 microwave radiation, 414 – 418 and ultrasound. 419 All these observations reported so far suggest that the Cu-Cy NPs are a new type of sensitizers with potential applications for infection inactivation 420 and antitumor therapies.…”

Section: Treatmentmentioning

confidence: 99%

Colorectal liver metastasis: molecular mechanism and interventional therapy

Zhou

Liu

Wang

et al. 2022

Sig Transduct Target Ther

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142

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Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.

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Section: Treatmentmentioning

confidence: 99%

Colorectal liver metastasis: molecular mechanism and interventional therapy

Zhou

Liu

Wang

et al. 2022

Sig Transduct Target Ther

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142

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“…The researchers found that Cu-cysteamine complexes have lower cellular dark toxicity due to the low leaching rate of copper ions [27] . In this study, we explored the toxicity on PC12 nerve cells induced by this material we synthesized.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

PEG-modified Copper Cysteine for Photodynamic Therapy in Alzheimer's Disease

Song

Yang

et al. 2022

Preprint

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As a progressive neurodegenerative disease, Alzheimer's disease (AD) is characterized by the accumulation and misfolding of amyloid polypeptides (Aβ) which result in irreversible brain damages, cognitive decline and behavioral impairment. Photodynamic therapy (PDT) has received much attention as a potential approach for AD treatment. In this study, we investigated a novel multifunctional theranostic photosensitizer, copper cysteine (Cu-Cy). By performing PEG modification on nanoparticles’ surface, the particle size and cytotoxicity were significantly reduced. Under UV irradiation, Cu-Cy-PEG can produce reactive oxygen species (ROS) and could degrade Aβ(1-40) aggregates efficiently. This is the first case for Cu-Cy-PEG being used for degrading Aβ aggregates in vitro. The macroscopic amyloid aggregates were photodegraded by Cu-Cy-PEG into amorphous particles. This study firstly proved that Cu-Cy-PEG may serve as a potential treatment in AD therapy.

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“…MTT experiments were used to evaluate the lethality of Cu-MOF, Cu-MOF/GOD and Cu-MOF/GOD@HA [37][38][39][40]. The viabilities of MCF-7 cells treated with Cu-MOF, Cu-MOF/GOD and Cu-MOF/GOD@HA at several concentrations (0, 10, 20, 30, 50, 70, 100 µg mL -1 ) levels were calculated, as illustrated in Figure 4A.…”

Section: Cell Experimentsmentioning

confidence: 99%

Construction of Novel Nanocomposites (Cu-MOF/GOD@HA) for Chemodynamic Therapy

Hao

Shu

et al. 2021

Nanomaterials

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The emerging chemodynamic therapy (CDT) has received an extensive attention in recent years. However, the efficiency of CDT is influenced due to the limitation of H2O2 in tumor. In this study, we designed and synthesized a novel core-shell nanostructure, Cu-metal organic framework (Cu-MOF)/glucose oxidase (GOD)@hyaluronic acid (HA) (Cu-MOF/GOD@HA) for the purpose of improving CDT efficacy by increasing H2O2 concentration and cancer cell targeting. In this design, Cu-MOF act as a CDT agent and GOD carrier. Cu(II) in Cu-MOF are reduced to Cu(I) by GSH to obtain Cu(I)-MOF while GSH is depleted. The depletion of GSH reinforces the concentration of H2O2 in tumor to improve the efficiency of CDT. The resultant Cu(I)-MOF catalyze H2O2 to generate hydroxyl radicals (·OH) for CDT. GOD can catalyze glucose (Glu) to supply H2O2 for CDT enhancement. HA act as a targeting molecule to improve the targeting ability of Cu-MOF/GOD@HA to the tumor cells. In addition, after loading with GOD and coating with HA, the proportion of Cu(I) in Cu-MOF/GOD@HA is increased compared with the proportion of Cu(I) in Cu-MOF. This phenomenon may shorten the reactive time from Cu-MOF to Cu(I)-MOF. The CDT enhancement as a result of GOD and HA effects in Cu-MOF/GOD@HA was evidenced by in vitro cell and in vivo animal studies.

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A new type of cuprous-cysteamine sensitizers: Synthesis, optical properties and potential applications

Cited by 14 publications

References 70 publications

Colorectal liver metastasis: molecular mechanism and interventional therapy

Colorectal liver metastasis: molecular mechanism and interventional therapy

PEG-modified Copper Cysteine for Photodynamic Therapy in Alzheimer's Disease

Construction of Novel Nanocomposites (Cu-MOF/GOD@HA) for Chemodynamic Therapy

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