A new water absorbable mechanical Epidermal skin equivalent: The combination of hydrophobic PDMS and hydrophilic PVA hydrogel

Morales-Hurtado, M.; Zeng, Xiangqiong; Gonzalez-Rodriguez, Pablo J.; Elshof, Johan E. ten; Heide, Emile van der

doi:10.1016/j.jmbbm.2015.02.014

Cited by 52 publications

(31 citation statements)

References 49 publications

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“…As described above, numerous mechanical tests have been conducted on human skin to obtain a better understanding of the nature of this complex material, whereas mechanical properties of veins have been much less frequently investigated than arteries, which are the site affected in the majority of patients with vascular diseases. Regarding tissue-mimicking materials, currently, commercially available skin equivalents are mainly used to heal skin damage by protecting the skin from bacteria or to deliver drugs 110 . Therefore, the mechanical properties of these skin substitutes are not representative of human skin.…”

Section: Materials Mimicking Human Soft Tissuesmentioning

confidence: 99%

Guidelines for designing a realistic peripheral venous catheter insertion simulator: A literature review

Torossian

Benayoun

Otténio

et al. 2019

Proc Inst Mech Eng H

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A literature review was conducted to develop more realistic medical simulators that better prepare aspiring health professionals to perform a medical procedure in vivo. Thus, this review proposes an approach that might assist researchers design improved medical simulators, particularly new materials that would enhance the sensation of touch for skin substitutes. By targeting the current needs in the field of simulation learning, we concluded that peripheral venous catheter insertion simulators lack realistic haptic feedback. Enhanced peripheral venous catheter insertion simulators will accelerate the mastery of the medical procedure, thus decreasing the number of failures in patients and costs related to this procedure.

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Section: Materials Mimicking Human Soft Tissuesmentioning

confidence: 99%

Guidelines for designing a realistic peripheral venous catheter insertion simulator: A literature review

Torossian

Benayoun

Otténio

et al. 2019

Proc Inst Mech Eng H

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“…Also, equilibrium water content (ECW) of ESE was found around 38.8% and elastic modulus between 0.1-1.5 MPa as shown dependency on the water content. In addition, ESE showed a viscoelastic behavior having shear modulus between 1-2.5 MPa, variable with frequency, temperature, and hydration of the composite hydrogels[227].4.3.4. PolyurethanesPolyurethanes (PU) are segmented polymers with alternating soft and hard segments and their overall properties can be tailored chemically to meet specific property requirements by selecting different soft segments and processing conditions.…”

mentioning

confidence: 97%

PVA-based hydrogels for tissue engineering: A review

Kumar

Han

2016

International Journal of Polymeric Materials and Polymeric Biom

385

161

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Poly (vinyl alcohol) (PVA) is a hydrophilic polymer with excellent biocompatibility and has been applied in various biomedical areas due to its favorable properties. PVA-based hydrogels have been recognized as promising biomaterials and suitable candidate for tissue engineering applications and can be manipulated to act various critical roles.However, due to some disadvantages (i.e., lack of cell-adhesive property), it needs further modification for desired and targeted applications. This review highlights recent progress in the design and fabrication of PVA-based hydrogels, including cross-linking and processing techniques. Finally, major challenges and future perspectives in tissue engineering are briefly discussed. GRAPHICAL ABSTRACTDownloaded by [University of Sussex Library] at 08:36 28 June 2016 2

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“…The main advantages of silicone based models are related to the broad range of properties that can be simulated, easy manipulation, nontoxicity during and after preparation, and long‐term stability. Silicone based skin models have been introduced to simulate skin in numerous applications such as optical imaging, measurement of the specific absorption rate , drug delivery , needle penetration , acoustic and photoacoustic imaging , tactile assessment , indentation , and friction .…”

Section: Elastomersmentioning

confidence: 99%