A Newly Characterized Potentially Probiotic Strain, Lactobacillus brevis MK05, and the Toxicity Effects of its Secretory Proteins Against MCF-7 Breast Cancer Cells

Pourbaferani, Mona; Modiri, Sima; Norouzy, Amir; Maleki, Hadi; Heidari, Mohadeseh; Alidoust, Leila; Derakhshan, Venus; Zahiri, Hossein Shahbani; Noghabi, Kambiz Akbari

doi:10.1007/s12602-021-09766-8

Cited by 24 publications

(16 citation statements)

References 34 publications

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“…Altogether, these data point out a possible role of managing the microbiome to provide novel leverage on breast cancer. These strategic considerations encompass the use of prebiotics [36], probiotics [37][38][39][40][41][42][43][44][45], diverse nutrition [46][47][48][49], and the careful use antibiotics to reduce the risk for breast cancer incidence and recurrence [22][23][24][25][26][27][28][29][30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

“…As noted earlier, risk factors for breast cancer lead to decreases in diversity, such as high-density breast [50], early menarche [51], low physical activity [51], and increases in BMI [51,52]. Furthermore, antibiotic overdose, which leads to lower diversity, increases the risk for breast cancer [22,23,[25][26][27][28][29][30][31][32], while probiotics that increase diversity have a protective effect [37][38][39][40][41][42][43][44][45].…”

Section: Bacterial Metabolite Signaling and The Oncobiosis Of The Gastrointestinal Tract And Urinary Tractmentioning

confidence: 91%

“…Namely, Staphylococcus negatively covaried with TRAF4 , Pelomonas positively covaried and Bradyrhizobium negatively covaried with VEGF-A, and Propionibacterium negatively covaried with PDGF-AA and PDGF-BB. In addition to these data, circumstantial data suggest bacterial secretory proteins [ 41 ] are probably also involved in communication between the microbiome and tumor tissue.…”

Section: Interactions Between the Oncobiome Tumors And Tumor Cellsmentioning

confidence: 94%

“…The causative role of oncobiosis in the pathogenesis of breast cancer is underscored by the observations that antibiotic use increases the risk for breast cancer in mice [22][23][24], and the majority of studies suggest an increased risk in humans, also [25][26][27][28][29][30][31][32][33] (it should be noted that [34] and [35] found no association between antibiotic exposure and breast cancer risk). In further support of the pathological role of the microbiome, prebiotics [36], probiotics [37][38][39][40][41][42][43][44][45], and diverse nutrition [46][47][48][49] reduce the risk of breast cancer. Furthermore, risk factors of breast cancer, such as high-density breast [50], early menarche [51], low physical activity [51], increases in BMI [51,52], age [53], and alcohol consumption [54], are also associated with microbiome changes culminating in breast cancer-associated oncobiosis.…”

Section: Oncobiosis In Breast Cancermentioning

confidence: 99%

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The involvement of oncobiosis and bacterial metabolite signaling in metastasis formation in breast cancer

Kovàcs

Mikó

Ujlaki

et al. 2021

Cancer Metastasis Rev

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Breast cancer, the most frequent cancer in women, is characterized by pathological changes to the microbiome of breast tissue, the tumor, the gut, and the urinary tract. Changes to the microbiome are determined by the stage, grade, origin (NST/lobular), and receptor status of the tumor. This year is the 50th anniversary of when Hill and colleagues first showed that changes to the gut microbiome can support breast cancer growth, namely that the oncobiome can reactivate excreted estrogens. The currently available human and murine data suggest that oncobiosis is not a cause of breast cancer, but can support its growth. Furthermore, preexisting dysbiosis and the predisposition to cancer are transplantable. The breast’s and breast cancer’s inherent microbiome and the gut microbiome promote breast cancer growth by reactivating estrogens, rearranging cancer cell metabolism, bringing about a more inflammatory microenvironment, and reducing the number of tumor-infiltrating lymphocytes. Furthermore, the gut microbiome can produce cytostatic metabolites, the production of which decreases or blunts breast cancer. The role of oncobiosis in the urinary tract is largely uncharted. Oncobiosis in breast cancer supports invasion, metastasis, and recurrence by supporting cellular movement, epithelial-to-mesenchymal transition, cancer stem cell function, and diapedesis. Finally, the oncobiome can modify the pharmacokinetics of chemotherapeutic drugs. The microbiome provides novel leverage on breast cancer that should be exploited for better management of the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Bacterial Metabolite Signaling and The Oncobiosis Of The Gastrointestinal Tract And Urinary Tractmentioning

confidence: 91%

Section: Interactions Between the Oncobiome Tumors And Tumor Cellsmentioning

confidence: 94%

Section: Oncobiosis In Breast Cancermentioning

confidence: 99%

See 2 more Smart Citations

The involvement of oncobiosis and bacterial metabolite signaling in metastasis formation in breast cancer

Kovàcs

Mikó

Ujlaki

et al. 2021

Cancer Metastasis Rev

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“…L. brevis enjoys GRAS status (Generally Recognized As Safe) on the basis of their widespread historical use in various traditional fermented food products [ 48 ]. Strains of L. brevis can vary significantly with some possessing antipathogenic [ 49 ], antioxidant, immunomodulatory [ 50 ], anticarcinogenic [ 51 ] and antifungal [ 52 ] activity, all considered probiotic properties.…”

Section: Discussionmentioning

confidence: 99%

The effects of Levilactobacillus brevis on the physiological parameters and gut microbiota composition of rats subjected to desynchronosis

et al. 2021

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Background All living organisms have developed during evolution complex time-keeping biological clocks that allowed them to stay attuned to their environments. Circadian rhythms cycle on a near 24 h clock. These encompass a variety of changes in the body ranging from blood hormone levels to metabolism, to the gut microbiota composition and others. The gut microbiota, in return, influences the host stress response and the physiological changes associated with it, which makes it an important determinant of health. Lactobacilli are traditionally consumed for their prophylactic and therapeutic benefits against various diseases, namely, the inflammatory bowel syndrome, and even emerged recently as promising psychobiotics. However, the potential role of lactobacilli in the normalization of circadian rhythms has not been addressed. Results Two-month-old male rats were randomly divided into three groups and housed under three different light/dark cycles for three months: natural light, constant light and constant darkness. The strain Levilactobacillus brevis 47f was administered to rats at a dose of 0.5 ml per rat for one month and The rats were observed for the following two months. As a result, we identified the biomarkers associated with intake of L. brevis 47f. Changing the light regime for three months depleted the reserves of the main buffer in the cell—reduced glutathione. Intake of L. brevis 47f for 30 days restored cellular reserves of reduced glutathione and promoted redox balance. Our results indicate that the levels of urinary catecholamines correlated with light/dark cycles and were influenced by intake of L. brevis 47f. The gut microbiota of rats was also influenced by these factors. L. brevis 47f intake was associated with an increase in the relative abundance of Faecalibacterium and Roseburia and a decrease in the relative abundance of Prevotella and Bacteroides. Conclusions The results of this study show that oral administration of L. brevis 47f, for one month, to rats housed under abnormal lightning conditions (constant light or constant darkness) normalized their physiological parameters and promoted the gut microbiome's balance.

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Lactobacillus plantarum postbiotics trigger AMPK‐dependent autophagy to suppress Salmonella intracellular infection and NLRP3 inflammasome activation

Wu¹,

Hu²,

Shu³

et al. 2023

Journal Cellular Physiology

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We previously found that Lactobacillus plantarum (LP)‐derived postbiotics protected animals against Salmonella infection, but the molecular mechanism remains obscure. This study clarified the mechanisms from the perspective of autophagy. Intestinal porcine epithelial cells (IPEC‐J2) were pretreated with LP‐derived postbiotics (the culture supernatant, LPC; or heat‐killed bacteria, LPB), and then challenged with Salmonella enterica Typhimurium (ST). Results showed that LP postbiotics markedly triggered autophagy under ST infection, as indicated by the increased LC3 and Beclin1 and the decreased p62 levels. Meanwhile, LP postbiotics (particularly LPC) exhibited a strong capacity of inhibiting ST adhesion, invasion and replication. Pretreatment with the autophagy inhibitor 3‐methyladenine (3‐MA) led to a significant decrease of autophagy and the aggravated infection, indicating the importance of autophagy in LP postbiotics‐mediated Salmonella elimination. LP postbiotics (especially LPB) significantly suppressed ST‐induced inflammation by modulating inflammatory cytokines (the increased interleukin (IL)‐4 and IL‐10, and decreased tumor necrosis factor‐α (TNF), IL‐1β, IL‐6 and IL‐18). Furthermore, LP postbiotics inhibited NOD‐like receptor protein 3 (NLRP3) inflammasome activation, as evidenced by the decreased levels of NLRP3, Caspase‐1 and apoptosis‐associated speck‐like protein containing a caspase recruitment domain (ASC). Deficits in autophagy resulted in an increase of inflammatory response and inflammasome activation. Finally, we found that both LPC and LPB triggered AMP‐activated protein kinase (AMPK) signaling pathway to induce autophagy, and this was further confirmed by AMPK RNA interference. The intracellular infection and NLRP3 inflammasome were aggravated after AMPK knockdown. In summary, LP postbiotics trigger AMPK‐mediated autophagy to suppress Salmonella intracellular infection and NLRP3 inflammasome in IPEC‐J2 cells. Our findings highlight the effectiveness of postbiotics, and provide a new strategy for preventing Salmonella infection.

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A Newly Characterized Potentially Probiotic Strain, Lactobacillus brevis MK05, and the Toxicity Effects of its Secretory Proteins Against MCF-7 Breast Cancer Cells

Cited by 24 publications

References 34 publications

The involvement of oncobiosis and bacterial metabolite signaling in metastasis formation in breast cancer

The involvement of oncobiosis and bacterial metabolite signaling in metastasis formation in breast cancer

The effects of Levilactobacillus brevis on the physiological parameters and gut microbiota composition of rats subjected to desynchronosis

Lactobacillus plantarum postbiotics trigger AMPK‐dependent autophagy to suppress Salmonella intracellular infection and NLRP3 inflammasome activation

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