A NiFe PBA/AuNPs nanocomposite sensitive immunosensor for electrochemical detection of PSA

Hua, Xin; Zhao, Tongxiao; Gui, Xueqin; Jin, Baokang

doi:10.1039/d3ay02184j

Anal. Methods

2024

DOI: 10.1039/d3ay02184j

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A NiFe PBA/AuNPs nanocomposite sensitive immunosensor for electrochemical detection of PSA

Xin Hua,

Tongxiao Zhao,

Xueqin Gui

et al.

Abstract: In this paper, A label-free electrochemical immunosensor for sensitive detection of prostate antigen (PSA) was developed based on NiFe PBA/AuNPs composite. The prostate antigen antibody was immobilized and the immunosensor...

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Sandwich-Type Electrochemical Aptasensor with Supramolecular Architecture for Prostate-Specific Antigen

Villalonga,

Díaz,

Ojeda

et al. 2024

Molecules

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A novel sandwich-type electrochemical aptasensor based on supramolecularly immobilized affinity bioreceptor was prepared via host–guest interactions. This method utilizes an adamantane-modified, target-responsive hairpin DNA aptamer as a capture molecular receptor, along with a perthiolated β-cyclodextrin (CD) covalently attached to a gold-modified electrode surface as the transduction element. The proposed sensing strategy employed an enzyme-modified aptamer as the signalling element to develop a sandwich-type aptasensor for detecting prostate-specific antigen (PSA). To achieve this, screen-printed carbon electrodes (SPCEs) with electrodeposited reduced graphene oxide (RGO) and gold nanoferns (AuNFs) were modified with the CD derivative to subsequently anchor the adamantane-modified anti-PSA aptamer via supramolecular associations. The sensing mechanism involves the affinity recognition of PSA molecules on the aptamer-enriched electrode surface, followed by the binding of an anti-PSA aptamer–horseradish peroxidase complex as a labelling element. This sandwich-type arrangement produces an analytical signal upon the addition of H2O2 and hydroquinone as enzyme substrates. The aptasensor successfully detected the biomarker within a concentration range of 0.5 ng/mL to 50 ng/mL, exhibiting high selectivity and a detection limit of 0.11 ng/mL in PBS.

show abstract

Sandwich-Type Electrochemical Aptasensor with Supramolecular Architecture for Prostate-Specific Antigen

Villalonga,

Díaz,

Ojeda

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

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A NiFe PBA/AuNPs nanocomposite sensitive immunosensor for electrochemical detection of PSA

Abstract: In this paper, A label-free electrochemical immunosensor for sensitive detection of prostate antigen (PSA) was developed based on NiFe PBA/AuNPs composite. The prostate antigen antibody was immobilized and the immunosensor...

Cited by 1 publication

References 43 publications

Sandwich-Type Electrochemical Aptasensor with Supramolecular Architecture for Prostate-Specific Antigen

Sandwich-Type Electrochemical Aptasensor with Supramolecular Architecture for Prostate-Specific Antigen

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