2019
DOI: 10.1039/c8bm01440j
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A NIR-II fluorescent probe for articular cartilage degeneration imaging and osteoarthritis detection

Abstract: A Type II collagen-binding peptide based NIR-II fluorescent probe for articular cartilage degeneration imaging and early osteoarthritis detection.

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Cited by 40 publications
(34 citation statements)
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“…NIR-II probes CH1055-GK and CH1055-PEG (as a control) were synthesized with CH1055 and the peptide GRRRDEVDK or its control COtBu-PEG4-NH2 (Chart 1 and Figure S1). As reported in our previous work, the NIR absorption bands of CH1055-WYRGRL (CH1055-WL) exhibited high stability and photostability, which would allow the probe to emit stable fluorescence in living organisms for a long time (Yi et al, 2019). Similarly, in this study, we designed the CH1055-GK probe, and the MALDI-TOF-MS measurement result for CH1055-GK was 2.064 KDa, while the expected M.W.…”
Section: Resultsmentioning
confidence: 77%
“…NIR-II probes CH1055-GK and CH1055-PEG (as a control) were synthesized with CH1055 and the peptide GRRRDEVDK or its control COtBu-PEG4-NH2 (Chart 1 and Figure S1). As reported in our previous work, the NIR absorption bands of CH1055-WYRGRL (CH1055-WL) exhibited high stability and photostability, which would allow the probe to emit stable fluorescence in living organisms for a long time (Yi et al, 2019). Similarly, in this study, we designed the CH1055-GK probe, and the MALDI-TOF-MS measurement result for CH1055-GK was 2.064 KDa, while the expected M.W.…”
Section: Resultsmentioning
confidence: 77%
“…With excellent hydrophilic ability, PEG chains grafted on nanoparticle generate a su ciently thick hydrated cloud [35] that strongly prevents NPs from aggregation. Functionalized with low molecular weight PEG, nanomaterials have enhanced penetration ability through mucus [36] and other tissues, which facilitated drug delivery to the lung [37], breast [38] and colorectal carcinomas [39]. CollB-peptide has been demonstrated to bind to collagen II α1 and shows outstanding application in drug delivery and imaging [28,40].…”
Section: Discussionmentioning
confidence: 99%
“…Functionalization of poly(propylene sulphide nanoparticles and subsequent IA injection in mice knees resulted in a 72‐fold increase in cartilage‐targeting ability compared to nanoparticles functionalized with the scrambled control 103 . In contrast to other reported peptides, this sequence has been successfully used in preclinical models for diagnostics and drug delivery applications 12,91,103‐106 . In fact, the conjugation of this peptide to magnetic resonance imaging (MRI) contrast agents has allowed in vivo localization of cartilage hypertrophic changes in a rat model of OA 104 .…”
Section: Targeting For Ia Drug Deliverymentioning
confidence: 99%