1999
DOI: 10.1016/s0091-3057(98)00252-4
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A Nitric Oxide Synthesis Inhibitor Administered Into the Medial Preoptic Area Increases Seminal Emissions in an Ex Copula Reflex Test

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Cited by 26 publications
(11 citation statements)
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“…These results suggest that NO generated in or near the AV3V may act to regulate the vasopressin release, arterial pressure and heart rate but it may not play an essential role in eliciting the responses of these variables to osmotic or prostaglandin E (2) stimuli as previously described by (Yamaguchi et al, 2000). Our findings are consistent with other hypothesis that NO is a tonic inhibitor of sympathetic nervous system tone, possibly in part through an influence on dopamine synthesis or release as has been demonstrated in the studies of (Moses and Hull, 1999). Ascending pathways from medial hypothalamus or LH to AV3V region were suggested by studies from our laboratory using cholinergic activation of these nuclei (Valadão et al, 1992).…”
Section: Discussionsupporting
confidence: 90%
“…These results suggest that NO generated in or near the AV3V may act to regulate the vasopressin release, arterial pressure and heart rate but it may not play an essential role in eliciting the responses of these variables to osmotic or prostaglandin E (2) stimuli as previously described by (Yamaguchi et al, 2000). Our findings are consistent with other hypothesis that NO is a tonic inhibitor of sympathetic nervous system tone, possibly in part through an influence on dopamine synthesis or release as has been demonstrated in the studies of (Moses and Hull, 1999). Ascending pathways from medial hypothalamus or LH to AV3V region were suggested by studies from our laboratory using cholinergic activation of these nuclei (Valadão et al, 1992).…”
Section: Discussionsupporting
confidence: 90%
“…increased mounting rate. In addition, Moses and Hull (1999) found that microinjection of L-NMMA into the MPOA significantly decreased the latency to the first erection or seminal emission and increased the number of seminal emissions in male rats. Both of those effects were hypothesized to result from enhanced sympathetic nervous system activity.…”
Section: Discussionmentioning
confidence: 95%
“…Interestingly, the THF-diols, but not the LTX-diols, block male sexual behavior (Mani et al 2005; Markaverich et al 2005). The mechanism of action of these compounds remains to be resolved, although we suspect their effects on estrous cyclicity and sexual behavior in male and female rats are mediated via the modulation of nitric oxide–dependent pathways controlling gonadotrophin-releasing hormone release (Hull et al 1994; Ishizaki et al 1995a, 1995b; Moses and Hull 1999). The present studies support a common mechanism of action.…”
Section: Discussionmentioning
confidence: 99%