A non-lipid nucleic acid delivery vector with dendritic cell tropism and stimulation
Hyung Shik Kim,
Elias A. Halabi,
Noah Enbergs
et al.
Abstract:Rationale
: Nucleic acid constructs are commonly used for vaccination, immune stimulation, and gene therapy, but their use in cancer still remains limited. One of the reasons is that systemic delivery to tumor-associated antigen-presenting cells (dendritic cells and macrophages) is often inefficient, while off-target nucleic acid-sensing immune pathways can stimulate systemic immune responses. Conversely, certain carbohydrate nanoparticles with small molecule payloads have been shown to target these… Show more
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