A non-toxic poly(resorcinol) modified glassy carbon electrode for highly selective square wave voltammetry determination of aspirin in tablet formulations and human urine samples

Kassa, Adane; Bitew, Zelalem; Abebe, Atakilt

doi:10.1016/j.sbsr.2023.100554

Cited by 9 publications

(13 citation statements)

References 30 publications

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“…The oxidative peaks current of 1.0 m m CQP was increased with the increasing number of cycles, which may be due to the increase in effective surface area of GCE as a result of modification (Figure 2 ). [ 16 , 18 , 21 ] Even though a considerable enhancement of oxidative peaks current was observed at each cycle, largest increment with highest slope was recorded by 20 cycles (Inset of Figure 2 ), beyond 20 cycles slight increase of peak current suggests that the overdose of the complex film at the GCE reduces its interaction with the electroactive functional group of CQP due to the saturation of the active sites. Therefore, 20 cycles were selected as the optimal condition for preparation of poly(DHRPCo)/GCE for determination of CQP in human blood serum, human urine and pharmaceutical formulation samples.…”

Section: Resultsmentioning

confidence: 98%

“…The observed current increment at pH 7.5 could partly be attributed the strong electrostatic attraction of the cationic CQP (p K a : 8.4), [1] with negatively charge poly(DHRPCo) film (phen, and reso with p K a values of 4.86&9.15, respectively). [ 16 , 18 , 21 ]…”

Section: Resultsmentioning

confidence: 99%

“…The oxidation peak current of CQP at poly(DHRPCo)/GCE increased with pH from 5.0 to 7.5 and then decreased beyond pH values of 7.5 (curve b of Figure 10B), making pH 7.5 the optimum for further electrochemical investigations of CQP. The observed current increment at pH 7.5 could partly be attributed the strong electrostatic attraction of the cationic CQP (p K a : 8.4), [1] with negatively charge poly(DHRPCo) film (phen, and reso with p K a values of 4.86&9.15, respectively) [16,18,21] …”

Section: Resultsmentioning

confidence: 99%

“…[ 17 , 18 ] Yet, electrochemical methods can be easily operated, requiring lower‐cost equipment, showing high sensitivity and precision, environmentally friendly and quick response. [ 16 , 17 , 18 , 19 , 20 , 21 ]…”

Section: Introductionmentioning

confidence: 99%

“…However, these methods show some disadvantages such as extended analysis time, complicated sample preparation steps, required trained manpower, high instrumental and analysis cost, which also contributes to the more significant production of chemical residues [17,18] . Yet, electrochemical methods can be easily operated, requiring lower‐cost equipment, showing high sensitivity and precision, environmentally friendly and quick response [16–21] …”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Determination of Chloroquine Phosphate in Real Samples Using a Diresorcinate‐1,10‐phenanthrolinecobalt(II)‐Modified Glassy Carbon Electrode

2023

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Chloroquine phosphate (CQP) is used for malaria treatment. As it is facing increasing resistance, it needs continuous monitoring using sensitive and specific detection methods. In this work, a voltammetric sensor was prepared by electropolymerization of a diresorcinate‐1,10‐phenanthrolinecobalt(II) complex on a glassy carbon electrode (poly(DHRPCo)/GCE) which was followingly characterized. Compared with a bare GCE, CQP showed single well shaped irreversible oxidative peak at the poly(DHRPCo)/GCE. The peak current showed excellent linearity with CQP concentration in the range of 0.005–300.0 μ m with a detection limit of 0.39 n m . The response of CQP at poly(DHRPCo)/GCE was not influenced by the presence of amoxicillin, ciprofloxacillin and paracetamol in addition to its high stability and reproducibility. It was applied for detection of CQP in various real samples, including three brands of tablets, human blood serum, and urine samples. The detected amount in tablets were in the range 98.4–103.2 % of their labeled value. Spike recovery results in human blood serum, urine, and tablet samples were 99.35–100.28 %, 99.03–100.32 %, and 98.40–100.41 %, respectively. Interference recovery results with less than 4.60 % error, the lower limit of detection and the wider dynamic range than most of the previously reported methods validate the potential applicability of the proposed method for CQP determination in various real samples with complex matrices.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Electrochemical Determination of Chloroquine Phosphate in Real Samples Using a Diresorcinate‐1,10‐phenanthrolinecobalt(II)‐Modified Glassy Carbon Electrode

2023

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A collection of the best practice examples of electroanalytical applications in education: from polarography to sensors

Cetinkaya,

Kaya,

Ozkan

2023

J Solid State Electrochem

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Eco-Friendly Synchronous Spectrofluorimetric Method for Simultaneous Determination of Remdesivir and Acetyl Salicylic Acid in Spiked Human Plasma

aboelghar,

Hegazy,

Wagdy

2024

J Fluoresc

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Remdesivir and acetyl salicylic acid are often co-administered medications in the treatment of COVID-19, specifically targeting the viral infection and thromboembolism associated with the condition. Hence, it is essential to establish a technique that enables the concurrent quantification of these pharmaceutical compounds in plasma while also keeping environmentally friendly methods. Accordingly, the aim of this work is to simultaneously determine remdesivir and acetyl salicylic acid through a bioanalytical validated synchronous spectrofluorimetric method with applying principles of green chemistry. Since, the two drugs showed severe overlap after excitation at 242.0 nm, 284.0 nm for remdesivir and acetyl salicylic acid, respectively. The overlap was effectively overcome by using synchronous mode with a wavelength difference (Δλ) of 160.0 nm for remdesivir and 100.0 nm for acetyl salicylic acid. Different parameters have been optimized such as Δλ, solvent, pH and surfactant. A linear calibration was obtained over the concentration range 0.01–4.00 µg/mL for remdesivir and 0.01–3.00 µg/mL for acetyl salicylic acid and the method was precise and accurate. The method was successfully used for the investigation of pharmaceutical formulation and the quantification of the maximum plasma concentration (Cmax) of the two drugs. The method has been evaluated as an excellent green analytical method based on three greenness assessment tools.

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A non-toxic poly(resorcinol) modified glassy carbon electrode for highly selective square wave voltammetry determination of aspirin in tablet formulations and human urine samples

Cited by 9 publications

References 30 publications

Electrochemical Determination of Chloroquine Phosphate in Real Samples Using a Diresorcinate‐1,10‐phenanthrolinecobalt(II)‐Modified Glassy Carbon Electrode

Electrochemical Determination of Chloroquine Phosphate in Real Samples Using a Diresorcinate‐1,10‐phenanthrolinecobalt(II)‐Modified Glassy Carbon Electrode

A collection of the best practice examples of electroanalytical applications in education: from polarography to sensors

Eco-Friendly Synchronous Spectrofluorimetric Method for Simultaneous Determination of Remdesivir and Acetyl Salicylic Acid in Spiked Human Plasma

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