A Noninvasive Portable Acoustic Diagnostic System to Differentiate Ischemic From Hemorrhagic Stroke

LaMonte, Marian P.; Sewell, John; Bahouth, Mona N.; Sewell, C.

doi:10.1111/j.1552-6569.2005.tb00286.x

Cited by 3 publications

(7 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ionic imbalances, and hyperglycolysis. [6][7][8][9]19 While these changes are most often transient, the challenge for sports medicine clinicians is to determine when full recovery occurs in an effort to prevent recurrent and/or late-life cognitive deficits.…”

Section: Discussionmentioning

confidence: 99%

“…1 Concussion leads to a well-documented cascade of neurometabolic events that result in the presentation of clinical signs and symptoms, such as headache, dizziness, amnesia, and difficulty concentrating. 6,8,9,19 Current diagnostic methods use a multifaceted approach including symptom scales, pre-and post-injury neuropsychological testing, and balance assessment. [3][4][5] The only truly objective measure of physiological function used currently occurs through neuroimaging, and, most often, findings are negative.…”

Section: Introductionmentioning

confidence: 99%

“…It is known that drastic ionic imbalances, reduced cerebral blood flow, and immediate increase in glycolytic activity result in a subsequent mismatch of oxygen supply and demand in the cerebrum. [6][7][8][9] This imbalance then leads to chronic hypoglycolysis and reduced cerebral blood flow days to weeks following injury-well after resolution of symptoms and return of neuropsychological function. [6][7][8][9][10][11] The Brain Acoustic Monitor (BAM) is a noninvasive device that detects changes in cerebral arterial function, which is common following both concussion and traumatic brain injury.…”

mentioning

confidence: 99%

“…[6][7][8][9] This imbalance then leads to chronic hypoglycolysis and reduced cerebral blood flow days to weeks following injury-well after resolution of symptoms and return of neuropsychological function. [6][7][8][9][10][11] The Brain Acoustic Monitor (BAM) is a noninvasive device that detects changes in cerebral arterial function, which is common following both concussion and traumatic brain injury. [12][13][14][15] This portable device detects, amplifies, and displays sound waves that are emitted through predictable deformations in the skull in response to each arterial pulse.…”

mentioning

confidence: 99%

“…8 In the initial stages of signal processing development, it was thought that the acoustic signals emitted by a healthy brain, as is received by the forehead sensors, would be similar to those emitted from a peripheral artery; whereas in an injured brain, the acoustic signals would sporadic and would not correlate with the pulse waves given by a peripheral artery. [7][8][9]74 As such, early studies with the BAM used two principal metrics for numerical assessment. The first, ratio, is measured directly from the time domain signal A follow-up to this study was performed to assess the correlation between the BAM signal measured early after admission for traumatic brain injury and subsequent anatomic and functional evidence of traumatic brain injury on cranial CT. 74 In this study, 206 traumatic brain injury patients were assessed and characterized as "normal" or "abnormal" and correlations calculated in accordance with findings on cranial CT.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Assessment of Cerebral Blood Flow Changes Following Concussion in Collegiate and High School Athletes

Spiers

View full text Add to dashboard Cite

Current recommendations for diagnosis and management of sport related concussion include patient-reported symptom inventories, computerized neurocognitive testing, and assessment of balance. There is a dire need for tools that are easily accessible and able to objectively measure physiological, not just functional, changes associated with concussion. The Brain Acoustic Monitor may offer a solution through examination of alterations in arterial functioning post-concussion. In this study, our purpose was to evaluate the potential usefulness of the Brain Acoustic Monitor in detecting changes in cerebral blood flow via measures of arterial stiffness in concussed individuals. In manuscript one, we sought to describe the test-retest reliability of Brain Acoustic Monitor measures and our results indicated moderate reliability over a 24 to 48 hour time period. Very low reliability was seen, however, in one of the eight measures, left systolic interval, suggesting potential sensor malfunction or inconsistency in processing methods. In manuscript two, we sought to describe post-concussion changes in arterial stiffness at 24 to 48 hours post-injury, resolution of symptoms, and return-to-activity. No significant differences in these three time points were found within our concussed sample; however, the concussed group displayed significantly higher right systolic interval at initial assessment and resolution of symptoms compared to a group of healthy age, gender, and sport-matched controls. These findings suggest the need for baseline measurements in future studies as well as a re-examination of processing procedures as there was large variability in some measures. In the third manuscript, we sought to determine how measures of arterial stiffness relate to current standards of concussion assessment, v

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Assessment of Cerebral Blood Flow Changes Following Concussion in Collegiate and High School Athletes

Spiers

View full text Add to dashboard Cite

show abstract

Auditory Signals for Noninvasive Monitors

Dutton¹,

Sewell²

2013

Monitoring in Neurocritical Care

View full text Add to dashboard Cite

Portable stroke detection devices: a systematic scoping review of prehospital applications

et al. 2022

View full text Add to dashboard Cite

Background The worldwide burden of stroke remains high, with increasing time-to-treatment correlated with worse outcomes. Yet stroke subtype determination, most importantly between stroke/non-stroke and ischemic/hemorrhagic stroke, is not confirmed until hospital CT diagnosis, resulting in suboptimal prehospital triage and delayed treatment. In this study, we survey portable, non-invasive diagnostic technologies that could streamline triage by making this initial determination of stroke type, thereby reducing time-to-treatment. Methods Following PRISMA guidelines, we performed a scoping review of portable stroke diagnostic devices. The search was executed in PubMed and Scopus, and all studies testing technology for the detection of stroke or intracranial hemorrhage were eligible for inclusion. Extracted data included type of technology, location, feasibility, time to results, and diagnostic accuracy. Results After a screening of 296 studies, 16 papers were selected for inclusion. Studied devices utilized various types of diagnostic technology, including near-infrared spectroscopy (6), ultrasound (4), electroencephalography (4), microwave technology (1), and volumetric impedance spectroscopy (1). Three devices were tested prior to hospital arrival, 6 were tested in the emergency department, and 7 were tested in unspecified hospital settings. Median measurement time was 3 minutes (IQR: 3 minutes to 5.6 minutes). Several technologies showed high diagnostic accuracy in severe stroke and intracranial hematoma detection. Conclusion Numerous emerging portable technologies have been reported to detect and stratify stroke to potentially improve prehospital triage. However, the majority of these current technologies are still in development and utilize a variety of accuracy metrics, making inter-technology comparisons difficult. Standardizing evaluation of diagnostic accuracy may be helpful in further optimizing portable stroke detection technology for clinical use.

show abstract

A Noninvasive Portable Acoustic Diagnostic System to Differentiate Ischemic From Hemorrhagic Stroke

Abstract: In a pilot study using a noninvasive monitor, the authors detected a potential to differentiate between normal subjects and those with cerebral ischemia or hemorrhage.

Cited by 3 publications

References 3 publications

Assessment of Cerebral Blood Flow Changes Following Concussion in Collegiate and High School Athletes

Assessment of Cerebral Blood Flow Changes Following Concussion in Collegiate and High School Athletes

Auditory Signals for Noninvasive Monitors

Portable stroke detection devices: a systematic scoping review of prehospital applications

Contact Info

Product

Resources

About