A Noninvasive Procedure for Early-Stage Discrimination of Malignant and Precancerous Vocal Fold Lesions Based on Laryngeal Dynamics Analysis

Zhang

et al. 2016

Acta Oto-Laryngologica

Conclusion This study indicates that IL-10 promoter polymorphism variants, smoking, and alcohol consumption increase the risk of recurrence and canceration in vocal leukoplakia. Objective This prospective, clinical trial was performed to evaluate the association of interleukin (IL)-10 promoter polymorphism variants and canceration and recurrence rates in vocal leukoplakia (a pre-cancerous laryngeal carcinoma lesion) over a 2-year period. Participants and method Sixty-one post-operative patients with vocal leukoplakia were enrolled in this prospective, observational study and genotyped for the IL-10 promoter gene (IL-10-1082 A/G, -819 T/C and -592 A/C) using pyrosequencing, and responded to a 2-year follow-up survey. Recurrence and canceration rates were used to evaluate the association between the genotype variants and the clinical outcome. Results There was an increased canceration rate in the variant genotype group compared to that in the normal genotype group in the 2-year follow-up period (18.4% vs 0%, p-value = 0.038). Compared with the non-smoker group, the smoker group had a higher recurrence rate of vocal leukoplakia (29.3% vs 5%, p-value =0.044). Likewise, the recurrence rate in the alcohol consumption group was also higher (30.6% vs 8%, p-value =0.034). The percentage of cancerization in the alcohol consumption group was significantly higher than that in the non-alcohol consumption group (19.4% vs 0%, p-value =0.035).

Section: Introductionmentioning

confidence: 99%

Association of the recurrence and canceration rate of vocal leukoplakia with interleukin-10 promoter variants over a 2-year period

Zhang

et al. 2016

Acta Oto-Laryngologica

“…For HSI‐interpretation, the synchronous or asynchronous movement of the vocal folds was considered as the most essential parameter. In a previous study it was found that in malignant lesions the affected vocal fold moves towards the glottic midline earlier than the healthy vocal fold. This could be explained by the fact that cancers per definition disrupt the basement membrane and often invade the underlying musculature and thus make the vocal fold stiffer.…”

Section: Resultsmentioning

confidence: 97%

“…White light imaging, NBI and HSI seem complementary rather than competitive optical tools in the diagnostic workup of laryngeal lesions. While NBI is focusing on the morphological appearance of lesions by showing their superficial extension and changes in vascularization [1,8,11,12,17,18,39], HSI is focusing on vocal fold function [22].…”

Section: Discussionmentioning

confidence: 99%

“…The method allows to show and measure vocal fold dynamics by yielding 4,000 white light images per second. The detection of changes in vocal fold dynamics enables to draw certain conclusions with regards on the dignity of a lesion [21][22][23]. HSI-videos are suited for a computerized analysis and quantification of vocal fold dynamics [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the combined use of narrow band imaging and high‐speed imaging to discriminate laryngeal lesions

et al. 2017

Self Cite

NBI and HSI both seem to be promising adjunct tools in the differentiation of various laryngeal lesions in awake patients with high sensitivities. Specificities, however, were moderate but could be increased when using NBI and HSI in combination in a subgroup of patients with only primary lesions. Although both methods still have limitations they might ameliorate the evaluation of suspicious laryngeal lesions in the future and could possibly spare patients from repeated invasive tissue biopsies. Lasers Surg. Med. 49:609-618, 2017. © 2017 Wiley Periodicals, Inc.

BioMed Research International

“…The parameters considered were chosen because (1) they are already frequently applied in daily clinical routine and in other studies, (2) they reflect different characteristics of the vocal folds and glottis dynamics, and (3) they are computed on different spaces (spectral and time space of the GAW). Although there are certainly more objective parameters being used in HSV analysis [8, 23, 29], the consideration of all possible HSV parameters would go far beyond one study. The primary goal of our study was to determine if there is a frame rate dependence among the HSV parameters.…”

Section: Methodsmentioning

confidence: 99%

Laryngeal High-Speed Videoendoscopy: Sensitivity of Objective Parameters towards Recording Frame Rate

Schützenberger

Döllinger

Dubrovskiy

et al. 2016

The current use of laryngeal high-speed videoendoscopy in clinic settings involves subjective visual assessment of vocal fold vibratory characteristics. However, objective quantification of vocal fold vibrations for evidence-based diagnosis and therapy is desired, and objective parameters assessing laryngeal dynamics have therefore been suggested. This study investigated the sensitivity of the objective parameters and their dependence on recording frame rate. A total of 300 endoscopic high-speed videos with recording frame rates between 1000 and 15 000 fps were analyzed for a vocally healthy female subject during sustained phonation. Twenty parameters, representing laryngeal dynamics, were computed. Four different parameter characteristics were found: parameters showing no change with increasing frame rate; parameters changing up to a certain frame rate, but then remaining constant; parameters remaining constant within a particular range of recording frame rates; and parameters changing with nearly every frame rate. The results suggest that (1) parameter values are influenced by recording frame rates and different parameters have varying sensitivities to recording frame rate; (2) normative values should be determined based on recording frame rates; and (3) the typically used recording frame rate of 4000 fps seems to be too low to distinguish accurately certain characteristics of the human phonation process in detail.