A Nonionic Porphyrin as a Noninterfering DNA Antibacterial Agent

Mendes, Sónia; Camacho, Fábio; Silva, Tito; Calado, Cecı́lia R.C.; Serra, Arménio C.; Gonsalves, Α. Μ. d’A. Rocha; Roxo-Rosa, Mónica

doi:10.1111/j.1751-1097.2011.00984.x

Cited by 5 publications

(4 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, we do not see any change in sensitivity to TAPP or to other antibiotics throughout these experiments. These results are in accordance with previous experiments for other porphyrins conducted by Mendes et al [32]. …”

Section: Discussionsupporting

confidence: 94%

Photo-activated porphyrin in combination with antibiotics: Therapies against Staphylococci

Dastgheyb

Eckmann

Composto

et al. 2013

Journal of Photochemistry and Photobiology B: Biology

View full text Add to dashboard Cite

Staphylococcal infections have become difficult to treat due to antibiotic insensitivity and resistance. Antimicrobial combination therapies may minimize acquisition of resistance and photodynamic therapy is an attractive candidate for these combinations. In this manuscript, we explore combined use of antibiotics and meso-tetra (4-aminophenyl) porphine (TAPP), a cationic porphyrin, for treatment of Staphylococcus aureus contamination. We characterize the antimicrobial activity of photoactivated TAPP and show that activity is largely lost in the presence of a radical scavenger. Importantly, TAPP can be reactivated with continued, albeit attenuated, antibacterial activity. We then show that the antimicrobial activity of illuminated TAPP is additive with chloramphenicol and tobramycin for Staphylococcus aureus and Escherichia coli, and synergistic for MRSA and Staphylococcus epidermidis. Chloramphenicol + methylene blue, another photosensitizer, also show additivity against Staphylococcus aureus. In contrast, ceftriaxone and vancomycin do not strongly augment the low level effects of TAPP against S. aureus. Eukaryotic cells exhibit a dose-dependent toxicity with illuminated TAPP. Our results suggest that even sub-minimum inhibitory concentration levels of photo-activated TAPP could be used to boost the activity of waning antibiotics. This may play an important role in treatments reliant on antibiotic controlled release systems where augmentation with photo-active agents could extend their efficacy.

show abstract

Section: Discussionsupporting

confidence: 94%

Photo-activated porphyrin in combination with antibiotics: Therapies against Staphylococci

Dastgheyb

Eckmann

Composto

et al. 2013

Journal of Photochemistry and Photobiology B: Biology

View full text Add to dashboard Cite

show abstract

“…One novel and promising approach to treat infections involving the presence of different pathogens relies on the use of photodynamic inactivation (PDI) [193] that consists of the local overproduction of ROS to inactivate microbes. This process is mediated by a non-toxic dye or a photosensitizer (PS) and light of low intensity (milliwatt range).…”

Section: Polymers Containing Photosensitizers: a New Class Of Biocmentioning

confidence: 99%

Recent Developments in Antimicrobial Polymers: A Review

et al. 2016

View full text Add to dashboard Cite

Antimicrobial polymers represent a very promising class of therapeutics with unique characteristics for fighting microbial infections. As the classic antibiotics exhibit an increasingly low capacity to effectively act on microorganisms, new solutions must be developed. The importance of this class of materials emerged from the uncontrolled use of antibiotics, which led to the advent of multidrug-resistant microbes, being nowadays one of the most serious public health problems. This review presents a critical discussion of the latest developments involving the use of different classes of antimicrobial polymers. The synthesis pathways used to afford macromolecules with antimicrobial properties, as well as the relationship between the structure and performance of these materials are discussed.

show abstract

“…( Figure ) This porphyrin can initiate PDI of both S. aureus and E. coli . Although higher MIC was required, it was proven to have less cytotoxicity side effects on the two mammalian cells lines as compared with 5,10,15,20‐tetrakis(4‐N,N,N‐trimethylammoniumphenyl)‐porphyrin p ‐tosylate (TTAP 4+ ) …”

Section: Types Of Porphyrin Based Compounds For Anti‐microbial Pdi Trmentioning

confidence: 99%

A Perspective on the Trends and Challenges Facing Porphyrin‐Based Anti‐Microbial Materials

Gan

Gao

et al. 2016

Small

125

106

View full text Add to dashboard Cite

The emergence of multidrug resistant bacterium threatens to unravel global healthcare systems, built up over centuries of medical research and development. Current antibiotics have little resistance against this onslaught as bacterium strains can quickly evolve effective defense mechanisms. Fortunately, alternative therapies exist and, at the forefront of research lays the photodynamic inhibition approach mediated by porphyrin based photosensitizers. This review will focus on the development of various porphyrins compounds and their incorporation as small molecules, into polymers, fibers and thin films as practical therapeutic agents, utilizing photodynamic therapy to inhibit a wide spectrum of bacterium. The use of photodynamic therapy of these porphyrin molecules are discussed and evaluated according to their electronic and bulk material effect on different bacterium strains. This review also provides an insight into the general direction and challenges facing porphyrins and derivatives as full-fledged therapeutic agents and what needs to be further done in order to be bestowed their rightful and equal status in modern medicine, similar to the very first antibiotic; penicillin itself. It is hoped that, with this perspective, new paradigms and strategies in the application of porphyrins and derivatives will progressively flourish and lead to advances against disease.

show abstract

A Nonionic Porphyrin as a Noninterfering DNA Antibacterial Agent

Cited by 5 publications

References 46 publications

Photo-activated porphyrin in combination with antibiotics: Therapies against Staphylococci

Photo-activated porphyrin in combination with antibiotics: Therapies against Staphylococci

Recent Developments in Antimicrobial Polymers: A Review

A Perspective on the Trends and Challenges Facing Porphyrin‐Based Anti‐Microbial Materials

Contact Info

Product

Resources

About