A nosocomial parvovirus B19 infection-induced transient aplastic crisis in a patient with chronic renal failure

Ozeki, Masahito; Fukushima, Toshihiro; Ohzeki, M; Sasaki, Takeshi; Kashihara, Noboru

doi:10.5414/cnp65141

Cited by 12 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this remains controversial. Nosocomial spread of infection in an enclosed dialysis unit is also a potential threat, but this is not well described in the literature (74).…”

Section: Parvovirus Infection In Dialysis Populationsmentioning

confidence: 99%

Parvovirus B19 and the Kidney

Waldman¹,

Kopp²

2007

Clinical Journal of the American Society of Nephrology

116

105

View full text Add to dashboard Cite

“…However, this remains controversial. Nosocomial spread of infection in an enclosed dialysis unit is also a potential threat, but this is not well described in the literature (74).…”

Section: Parvovirus Infection In Dialysis Populationsmentioning

confidence: 99%

Parvovirus B19 and the Kidney

Waldman¹,

Kopp²

2007

Clinical Journal of the American Society of Nephrology

116

105

View full text Add to dashboard Cite

“…Symptoms are typically present during viremia, and then resolve when neutralizing antibodies are produced [5,7,21]. Most immunocompetent adults will only have mild symptoms related to reticulocytopenia and/or transient anemia related to the red blood cell lifespan and reserve [15]. Red cell aplasia, however, is seen in patients with hemolytic syndromes due to rapid red cell turnover, as well as immunocompromised hosts due to poor immune response to infection [5].…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Parvovirus B19 is transmitted through respiratory secretions due to viral shedding in viremic patients. Nosocomial infections have been reported [15]. Patients with active parvovirus infection should be isolated in the hospital.…”

Section: Preventionmentioning

confidence: 99%

“…Infection most frequently occurs via transmission of the virus in respiratory secretions, but it may also be contracted through blood transfusion, bone marrow, or organ transplantation [12][13][14]. Nosocomial and congenital transmission have also been documented [15,16]. While most adults have long-lived protective antibodies against parvovirus, severe infection may occur in individuals with depressed immune systems due to solid organ or bone marrow transplant, HIV, or other immunodeficiencies.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Parvovirus B19 Infection in Solid Organ Transplantation: Report of A Case and A Review

Newman¹,

Pursell²,

Pitrak³

2018

obm transplant

View full text Add to dashboard Cite

Infection with parvovirus B19 is common, with up to 55% of adults showing seropositive evidence of prior infection. Clinical disease can occur due to acute infection, chronic persistent viremia, rarely secondary infection, or possibly viral reactivation of latent virus. The clinical presentation of primary infection depends on age, the presence of a hematologic condition, and immune status. We report a renal transplant recipient who developed transfusion dependent anemia refractory to erythropoietin that responded to IgG replacement, although he had a relapsing course. It is an uncommon infection in solid organ transplant (SOT) recipients that has atypical features, usually presenting with pure red cell aplasia which is refractory to erythropoietin (EPO) and which can be transfusion dependent. Plasma polymerase chain reaction (PCR) measurement of DNA, both qualitative and quantitative, can be very helpful for diagnosis, but a negative test does not exclude infection. In those cases, bone marrow biopsy may be needed to document the viral infection. Due to immunosuppression, SOT recipients may not be able to mount a measurable antibody response; hence serologic diagnosis by antibody detection may be unreliable. Other end organ disease is even more unusual manifestation of parvovirus infection, but it can occur,

show abstract

“…Without sequence data from other circulating strains unrelated to this potential transmission event, the sequence data from D1 and R1 can potentially be interpreted as either that D1 and R1 are independently infected by two highly similar strains not differentiable by the partial sequences presented, or a single highly prevalent circulating strain. Nosocomial infections from infected staff or patient have been reported previously in the literature [2,3], and Juhl et al did not present data to exclude potential concurrent B19V infection within the ward in which R1 was a patient.In D2/R2, R2 did not show seroconversion after the alleged transfusion transmitted infection. The investigators proposed two possible reasons: antibody adsorption and permanent protein loss.…”

mentioning

confidence: 94%

Complexity in interpreting partial viral sequence data as supportive evidence for possible transfusion transmitted Parvovirus B19 infection

Chan

2015

Vox Sanguinis

View full text Add to dashboard Cite

Dear Editor,Juhl et al. in their recent article "Look-back study on recipients of Parvovirus B19 (B19V) DNA-positive blood components" presented identical partial sequencing data of B19V NS1 gene region and NS1-VP1 region from two donor-recipient pairs (D1/R1, D2/R2) to support their claim on transfusion transmission of B19V [1]. While the epidemiological data correlate with the investigators' conclusion, the same data presented can be alternatively interpreted and different conclusions can be drawn.In D1/R1, B19V seroconversion in R1 occurred after blood product transfusion. The two regions interrogated in the B19V DNA products from D1 and R1 were identical. On the other hand, the sequences from the German D1 and R1 differ from the reference strain from a geographically distinct region (Netherlands) by only two nucleotide positions, suggesting the circulating viruses in that part of Europe are highly similar. Without sequence data from other circulating strains unrelated to this potential transmission event, the sequence data from D1 and R1 can potentially be interpreted as either that D1 and R1 are independently infected by two highly similar strains not differentiable by the partial sequences presented, or a single highly prevalent circulating strain. Nosocomial infections from infected staff or patient have been reported previously in the literature [2,3], and Juhl et al. did not present data to exclude potential concurrent B19V infection within the ward in which R1 was a patient.In D2/R2, R2 did not show seroconversion after the alleged transfusion transmitted infection. The investigators proposed two possible reasons: antibody adsorption and permanent protein loss. But alternatively R2 could have been previously infected and the negative serology pre-transfusion could be explained by the exact same proposed reasons. The observed viral load post transfusion could be potentially explained by silent reactivation in a very sick patient. Furthermore, the absence of sequence data unrelated to the event and data excluding concurrent B19V infection within the ward in which R2 was a patient, again mean that independent infection events have not been excluded, and a confirmed transmission between D2/R2 cannot be made.To infer transmission using molecular data, it is necessary to have sequences from unrelated strains to demonstrate the background of variations upon which the relationship among implicated strains is inferred. In highly conserved DNA viruses such as Parvovirus, this could be very difficult, especially when only short partial sequences are interrogated. References

show abstract

A nosocomial parvovirus B19 infection-induced transient aplastic crisis in a patient with chronic renal failure

Cited by 12 publications

References 0 publications

Parvovirus B19 and the Kidney

Parvovirus B19 and the Kidney

Parvovirus B19 Infection in Solid Organ Transplantation: Report of A Case and A Review

Complexity in interpreting partial viral sequence data as supportive evidence for possible transfusion transmitted Parvovirus B19 infection

Contact Info

Product

Resources

About