A novel 2-day desensitization protocol to oral mesalamine

5-Aminosalicylic acid intolerance is associated with a risk of adverse clinical outcomes and dysbiosis in patients with ulcerative colitis

“…21 Desensitization is generally performed during hospitalization by starting 5-ASA at a small dosage and gradually increasing the dose. 22,23 This treatment method is begun while the patient is still in the hospital because it enables prevention of emergency hospitalization and provision of adequate care for unexpected serious adverse events; furthermore, the effectiveness of desensitization remains controversial. 24 In the present study, we aimed to begin the development of alternative therapeutic strategies for 5-ASA continuation in 5-ASA-intolerant patients.…”

Mesalazine allergy and an attempt at desensitization therapy in patients with inflammatory bowel disease

“…Many reports indicated that the success rate of desensitization therapy with salazosulfapyridine is more than 80% in patients intolerant to salazosulfapyridine [21][22][23][24] , and recent reports have shown that desensitization therapy with mesalazine is effective for mesalazine intolerance, yielding relatively good outcomes 1,14,25,26 . In the present study, desensitization therapy with a time-dependent mesalazine granule formulation (PENTASA) was performed in ten patients.…”

“…The use of this formulation is preferable for desensitization therapy in which the dose is gradually increased. Although there are reports of desensitization therapy performed in an inpatient setting for a short period of time [25][26][27] , no consensus has been reached on incremental dosing regimens, which remain controversial. Regarding the precautions to be taken while initiating desensitization therapy, we consider that desensitization therapy should not be performed in patients with organ disorders, such as agranulocytosis, liver disorders, and lung disorders.…”