2021
DOI: 10.1016/j.bbih.2021.100363
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A novel adverse effect of the BNT162b2 mRNA vaccine: First episode of acute mania with psychotic features

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Cited by 19 publications
(27 citation statements)
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“…There are few case reports of development of psychosis after administration of vaccines for rabies ( Bhojani et al, 2014 ), yellow fever ( Romeo et al, 2021 ), smallpox, typhus and influenza. With respect to COVID-19 vaccine, few published case report has documented the association of psychosis with the use of vaccine and some of the reports indicate that psychosis could be an outcome of autoimmune encephalitis ( Reinfeld et al, 2021 ; Roberts et al, 2021 ; Takata et al, 2021 ; Yesilkaya et al, 2021 ).…”
Section: Discussionmentioning
confidence: 99%
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“…There are few case reports of development of psychosis after administration of vaccines for rabies ( Bhojani et al, 2014 ), yellow fever ( Romeo et al, 2021 ), smallpox, typhus and influenza. With respect to COVID-19 vaccine, few published case report has documented the association of psychosis with the use of vaccine and some of the reports indicate that psychosis could be an outcome of autoimmune encephalitis ( Reinfeld et al, 2021 ; Roberts et al, 2021 ; Takata et al, 2021 ; Yesilkaya et al, 2021 ).…”
Section: Discussionmentioning
confidence: 99%
“…Studies have shown that SAR-CoV-2 is known to trigger a powerful immune response, which includes the release of large amounts of pro-inflammatory cytokines. It is hypothesized that psychosis may be related to rapid increase in the proinflammatory response and activated autoimmune mechanism ( Yesilkaya et al, 2021 ). The MRI findings of tiny T2/FLAIR hyperintensities in deep white matter in bilateral fronto-parietal lobes in the index case could be indicators of the endothelial and autoimmune activation, as seen in autoimmune encephalitis.…”
Section: Discussionmentioning
confidence: 99%
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“… Giné-Servén et al, 2021 Not mentioned AstraZeneca COVID-19 vaccine (Viral vector vaccine) Psychosis (2 cases) Acute (7 hours and 12 days) Cycloid psychosis-like phenotype and marked cognitive impairment 8. Yesilkaya et al, 2021 42/M First dose of the BNT162b2 mRNA (mRNA vaccine) Mania with psychotic symptoms 1 day Irritability; sleeplessness; dysphoric mood; increased psychomotor activity; persecutory and referential delusions; loosening of associations 57/M Second dose of the BNT162b2 mRNA vaccine (mRNA vaccine) Mania with psychotic symptoms Same day Increased speech; increased psychomotor activity; decreased sleep; nihilistic delusion 9. Uvais, 2021 74/M First dose of ChAdOx1-S/nCoV- 19 vaccine (Viral vector vaccine) Depression 2 days Low mood, dryness of mouth, lack of interest in activities, marked reduction in appetite, and difficulty in initiating sleep.…”
Section: Search Strategy and Study Selectionmentioning
confidence: 99%
“…Both of them had dysphoric mood, irritability, increased speech, delusions, and absent insight. One of them developed symptoms on the same day of 2 nd dose of BNT162b2 mRNA vaccine and the other patient developed symptoms one day after his 1 st dose ( Yesilkaya et al, 2021 ). Another 74-year-old male developed depression after receiving the 1 st dose of ChAdOx1-S/nCoV- 19 adenoviral vector vaccine.…”
Section: Affective Disordersmentioning
confidence: 99%