A novel algorithmic approach to generate consensus treatment guidelines in adult acute myeloid leukaemia

Coats, Thomas; Bean, Daniel; Basset, Aymeric; Sirkis, Tamir; Brammeld, Jonathan; Johnson, Sean J.; Thomas, Ian; Gilkes, Amanda F.; Raj, Kavita; Dennis, Mike; Knapper, Steven; Mehta, Priyanka; Khwaja, Asim; Hunter, Hannah; Tauro, Sudhir; Bowen, David; Jones, Gail; Dobson, Richard; Russell, Nigel H.; Dillon, Richard

doi:10.1111/bjh.18013

Br J Haematol

2021

DOI: 10.1111/bjh.18013

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A novel algorithmic approach to generate consensus treatment guidelines in adult acute myeloid leukaemia

Thomas Coats

Daniel Bean

Aymeric Basset

et al.

Abstract: Induction therapy for acute myeloid leukaemia (AML) has changed with the ap-

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“…In their paper several biostatisticians and haematology colleagues propose a new algorithmic approach to developing consensus guidelines for treating acute myeloid leukaemia (AML). 1 The problem they want to address is that conventional consensus guidelines development cannot keep pace with the rapid evolution of AML therapies. The authors suggest their information-based approach is also relevant to other diseases where clinical decision-making is complex because of patient heterogeneity and the need to integrate multiple covariates.…”

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confidence: 99%

Everyone is entitled to his or her own opinion but not to their own facts*

Barosi

Gale

2022

Br J Haematol

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confidence: 99%

Everyone is entitled to his or her own opinion but not to their own facts*

Barosi

Gale

2022

Br J Haematol

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Best clinical practice recommendations for the management of symptomatic hemorrhoids via laser hemorrhoidoplasty: the LHP recommendations

Ambe,

Martin-Martin,

Vasas

et al. 2024

Tech Coloproctol

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Background Laser hemorrhoidoplasty (LHP) has emerged as a novel, minimally invasive technique for managing symptomatic hemorrhoids, gaining popularity among clinicians. Despite its increasing adoption, significant variations exist in the application of LHP across different practices. Purpose The aim of these recommendations was to spell out some basic principles and recommendations for performing a standard LHP procedure. Methods The Recommendation Development Group (RDG) consisting of surgeons with experience in LHP were invited to formulate recommendations for the procedure. The recommendations were generated following systematic literature research and discussion amongst experts (expert opinion) where no substantial literature was available. The developed recommendations were voted upon by a panelist via the Delphi process. Consensus was a priori defined as agreement of 75% and above, with strong consensus defined as 85% and above. Results The RDG developed 21 recommendations that were voted upon by 49 panelists. Consensus was reached for all 21 recommendations after the first Delphi round, including 16 recommendations with strong consensus. Conclusion The RDP offers a comprehensive suite of guidelines to enhance the safety and efficacy of standard LHP procedures. Out of 21 detailed recommendations, 16 reached strong consensus, collectively addressing the full spectrum of LHP procedures—from laser settings and preoperative preparations to perioperative strategies and postoperative care. This coherent framework is anticipated not only to standardize but also to refine the LHP technique across the board, thereby elevating the management of symptomatic hemorrhoidal disease.

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A novel algorithmic approach to generate consensus treatment guidelines in adult acute myeloid leukaemia

Abstract: Induction therapy for acute myeloid leukaemia (AML) has changed with the ap-

Cited by 2 publications

References 12 publications

Everyone is entitled to his or her own opinion but not to their own facts*

Everyone is entitled to his or her own opinion but not to their own facts*

Best clinical practice recommendations for the management of symptomatic hemorrhoids via laser hemorrhoidoplasty: the LHP recommendations

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