A novel alignment procedure to assess calcified coronary plaques in histopathology, post-mortem computed tomography angiography and optical coherence tomography

Precht, Helle; Broersen, Alexander; Kitslaar, Pieter H.; Dijkstra, Jouke; Gerke, Oke; Thygesen, Jesper; Egstrup, Kenneth; Leth, Peter Mygind; Hardt-Madsen, Michael; Nielsen, B; Falk, Erling; Lambrechtsen, Jess

doi:10.1016/j.carpath.2018.11.005

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…An improved method for mapping and registration of coronary arteries in longitudinal view on histopathology has recently been developed; this involves a three-dimensional alignment procedure for postmortem quantitative coronary plaque analyses [89]. This new procedure has been applied to calcified coronary plaque analyses comparing post-mortem computed tomography angiography (PMCTA), optical coherence tomography (OCT) and histopathology.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Pathobiology of cardiovascular diseases: an update

Buja

Ottaviani

Mitchell

2019

Cardiovascular Pathology

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This article introduces the Second Special Issue of Cardiovascular Pathology (CVP), the official journal of the Society for Cardiovascular Pathology (SCVP). This CVP Special Issue showcases a series of commemorative review articles in celebration of the 25 th anniversary of CVP originally published in 2016, and now compiled into a virtual collection with online access for the cardiovascular pathology community. This overview also provides updates on the major categories of cardiovascular diseases from the perspective of cardiovascular pathologists, highlighting publications from CVP, as well as additional important review articles and clinicopathologic references.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Pathobiology of cardiovascular diseases: an update

Buja

Ottaviani

Mitchell

2019

Cardiovascular Pathology

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A calcification subtraction method for postmortem coronary computed tomography angiography

Inokuchi,

Kojima,

Chiba

et al. 2024

Int J Legal Med

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Although coronary computed tomography (CT) angiography is a useful tool for evaluating coronary artery lesions both ante- and postmortem, accurate evaluation of the lumen is difficult when highly calcified lesions are present, owing to overestimation of stenosis caused by blooming and partial volume artifacts. In clinical practice, to overcome this diagnostic problem, a subtraction method has been devised to remove calcification by subtracting the precontrast image from the contrast image. In this report, we describe a calcification subtraction method using image analysis software for postmortem coronary CT angiography. This method was devised based on preliminary experimental results showing that the most accurate subtraction was achieved using images reconstructed with a narrower field of view and bone kernel, resulting in higher spatial resolution. This subtraction method allowed evaluation of lumen patency and the degree of stenosis on contrast-enhanced images in a verification using actual specimens where evaluation of the lumen had been difficult because of high calcification. The results were morphologically similar to the macroscopic findings. This method allows more rapid and reliable lesion retrieval and is expected to be useful for postmortem coronary angiography in forensic practice.

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