A novel all-3D-printed cell-on-a-chip device as a useful electroanalytical tool: Application to the simultaneous voltammetric determination of caffeine and paracetamol

Katseli, Vassiliki; Economou, Anastasios; Kokkinos, Christos

doi:10.1016/j.talanta.2019.120388

Cited by 82 publications

(39 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the advantages of using electrochemical techniques, even considering this new possibility of using polymer as an electrode, there are few studies in the literature, involving the analysis of substances of forensic interest in biological matrix 37 .…”

Section: Introductionmentioning

confidence: 99%

Disposable 3D Printed Electrode for the Electrochemical Detection of Delta-9-Tetrahydrocannabinol in Aqueous Solution and 11-Nor-9-Carboxy-Tetrahydrocannabinol in Saliva

Oiye

Ribeiro

Botelho³

et al. 2020

BJFS

View full text Add to dashboard Cite

Currently, marijuana or cannabis is the most consumed drug worldwide, and is also the one with the highest number of seizures, with 354 tons seized in Brazil in 2017. The increase in its consumption has been called attention, not only by the authorities, due to accidents caused when driving under the influence of the drug, but also by companies that carry out toxicological analyzes on their employees. For this, rapid tests, such as colorimetric tests, are generally used to analyze the urine of users. The need for agile and proper identification of drugs of abuse has encouraged the scientific community to improve and to develop new methodologies. Electrochemical methods appear as a cheap, portable and easy to use alternative. The use of biodegradable materials for the development of disposable electrodes has become paramount today. The use of 3D printers emerges as an alternative for the manufacture of these electrodes and the use of saliva instead of urine, has also been a priority because it is a less invasive sample and difficult to adulterate. In this work, a three dimensional device was created in an innovative way containing the three electrodes, working, counter and reference, in conductive material. The device was then used to detect the active principle present in cannabis, delta-9-tetrahydrocannabinol, in aqueous solution, and its metabolite, 11-nor-9-carboxy-THC, in samples of real saliva, both through cyclic voltammetry. The positive results show that the proposed device can be used, as well as those already found on the market, for the identification of drug use and in the forensic field.

show abstract

Section: Introductionmentioning

confidence: 99%

Disposable 3D Printed Electrode for the Electrochemical Detection of Delta-9-Tetrahydrocannabinol in Aqueous Solution and 11-Nor-9-Carboxy-Tetrahydrocannabinol in Saliva

Oiye

Ribeiro

Botelho³

et al. 2020

BJFS

View full text Add to dashboard Cite

show abstract

“…of its original activity for CAF, indicating the electrode was very stable. Graphene oxide-Nafion/GCE 2.0 0.20 [22] MWCNT-Nafion/GCE 4.1 0.51 [43] Nafion/GCE 1.0 0.79 [23] Nafion/MWCNT/GCE 2.0 0.23 [21] Attapulgite/Nafion/GCE 1.5 0.045 [26] 4-Cu II TAPc/SAM/GCE 4.0 0.0304 [44] ZnO/MWCNT/GCE 1.0 0.0097 [45] Pt-GR/GCE / 0.1129 [46] GORG/CPE/SDS 1.0 0.153 [47] GrRAC-70% / 2.94 [48] NCOM/CPE/SDS 0.75 0.016 [49] 3D-printed cell-on-a-chip / 2.84 [50] GCE / 20 [51] Nafion/PDDA-MWCNT/GCE 1.5 0.05 [52] Fullerene/MWCNT/Naf/GCE…”

Section: Interference Study Repeatability and Stability Of The Electmentioning

confidence: 99%

Fullerene/MWCNT/Nafion Modified Glassy Carbon Electrode for the Electrochemical Determination of Caffeine

Tajeu¹,

Dongmo²,

Tonlé³

2020

AJAC

View full text Add to dashboard Cite

Herein, a convenient method based on a fullerene/multiwalled carbon nanotube/Nafion modified glassy carbon electrode (fullerene/MWCNT/Naf/GCE) for the electrochemical determination of caffeine (CAF) is reported. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to study ionic exchange properties and conductivity the proposed electrode using [Fe(CN) 6 ] 3−/4− redox couple. Caffeine gave an irreversible oxidation peak around +1.33 V (vs. Ag/AgCl reference electrode) in HClO 4 (pH 1). The linear dependence of the peak current with the square root of the scan rate showed that the electron transfer process is controlled by diffusion. After optimization of key analytical parameters involved in differential pulse voltammetry (DPV), the oxidation peak current varied linearly with CAF concentration in the range of 10 to 1000 µM. A detection limit of 7.289 × 10 −8 M (S/N = 3) was found. Kinetic and chronocoulometric studies were also performed to characterize the diffusion of CAF. The developed electrode exhibited good stability and was easily regenerated. The influence of some potential interfering compounds such as dopamine, uric acid, glucose and sulfite ions on the anodic peak current of CAF was also examined. The proposed method was successfully employed in the determination of CAF in some commercial drugs.

show abstract

“…For the printing of counter and pseudo-reference electrodes, the same material (carbon-loaded PLA) is chosen for fabrication simplicity and speed. The use of 3D-printed carbon-loaded electrodes as a pseudo-reference electrode has been showed to be adequate for most electrochemical applications [33][34][35].…”

Section: Reagents and Apparatusmentioning

confidence: 99%

Voltammetric Determination of Pb(II) by a Ca-MOF-Modified Carbon Paste Electrode Integrated in a 3D-Printed Device

Vlachou

Margariti

Papaefstathìou

et al. 2020

Sensors

Self Cite

View full text Add to dashboard Cite

In this work, a voltammetric method based on a metal organic framework (Ca-MOF)-modified carbon paste electrode for lead determination was developed. The MOF-based electrode was packed in a new type of 3D-printed syringe-type integrated device, which was entirely fabricated by a dual extruder 3D printer. After optimization of the operational parameters, a limit of detection of 0.26 µg L−1 Pb(II) was achieved, which is lower than that of existing MOF-based lead sensors. The device was used for Pb(II) determination in fish feed and bottled water samples with high accuracy and reliability. The proposed sensor is suitable for on-site analyses and provides a low-cost integrated transducer for the ultrasensitive routine detection of lead in practical applications.

show abstract

A novel all-3D-printed cell-on-a-chip device as a useful electroanalytical tool: Application to the simultaneous voltammetric determination of caffeine and paracetamol

Cited by 82 publications

References 31 publications

Disposable 3D Printed Electrode for the Electrochemical Detection of Delta-9-Tetrahydrocannabinol in Aqueous Solution and 11-Nor-9-Carboxy-Tetrahydrocannabinol in Saliva

Disposable 3D Printed Electrode for the Electrochemical Detection of Delta-9-Tetrahydrocannabinol in Aqueous Solution and 11-Nor-9-Carboxy-Tetrahydrocannabinol in Saliva

Fullerene/MWCNT/Nafion Modified Glassy Carbon Electrode for the Electrochemical Determination of Caffeine

Voltammetric Determination of Pb(II) by a Ca-MOF-Modified Carbon Paste Electrode Integrated in a 3D-Printed Device

Contact Info

Product

Resources

About