2009
DOI: 10.1016/j.ejmech.2008.10.018
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A novel and efficient one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines and their anti-bacterial activity

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Cited by 195 publications
(42 citation statements)
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“…Pyrimido pyrimidines are annulated uracils that have attracted considerable interest in recent years. Derivatives of pyrimido pyrimidine are known to display a wide range of pharmacological activities, such as antiviral [6], antibacterial [7], antitumor [8], anti-inflammatory [9], antifungal [10], and antileishmanial agent [11] and their potent binding affinity towards the tyrosine kinase domain of epidermal growth factor receptor [12] has also been demonstrated.…”
Section: Introductionmentioning
confidence: 98%
“…Pyrimido pyrimidines are annulated uracils that have attracted considerable interest in recent years. Derivatives of pyrimido pyrimidine are known to display a wide range of pharmacological activities, such as antiviral [6], antibacterial [7], antitumor [8], anti-inflammatory [9], antifungal [10], and antileishmanial agent [11] and their potent binding affinity towards the tyrosine kinase domain of epidermal growth factor receptor [12] has also been demonstrated.…”
Section: Introductionmentioning
confidence: 98%
“…With growing application on their synthesis and bioactivity, chemists and biologists in recent years have directed considerable attention on the research of pyrazole derivatives. Pyrimidines are of chemical and pharmacological interest and compounds containing the pyrimidine ring system have been shown to possess antibacterial (Deshmukh et al, 2009), antifungal (Gholap et al, 2008), antimalarial (Azas et al 2003), anticonvulsant (Said et al 2009), and antitumor activities (Noll et al, 2009). Some are valuable drugs for the treatment of acute leukemia in children and adult granulocytic leukemia (Noll et al, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…Pyrazole and pyrazolones ring system plays an imperative role in wide range of biological activities such as antibacterial [11,12], antifungal [13], antimalarial [14], anticonvulsant, antitumor [15] and anti-inflammatory agents [16]. It is also interesting to note that pyrazoles are reported as well-known pharmacophores in targeting many diseases and in specific a potent Cannabinoid inhibitors are designed using pyrazole scaffold [17][18][19][20].…”
Section: Introductionmentioning
confidence: 99%