A Novel Animal Model for Hyaluronic Acid Filler Longevity

Filling Effects, Persistence, and Safety of Dermal Fillers Formulated With Stem Cells in an Animal Model

“…Similarly, other investigators have reported that the effects of experimental dermal fillers diminish with time in humans and animal models. 46,47 Our results indicate that ADSC-based formulations of dermal fillers produce greater FEs that persist significantly longer than dermal fillers prepared without ADSCs. Other researchers have observed trophic changes and modulation of the tissue environment when mesenchymal stem cells were applied to a reconstructed bladder wall in a rat model or injected into human skin as a filler component.…”